Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2010

Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer’s disease and mild cognitive impairment

Anna Zimny, Paweł Szewczyk, Anna Czarnecka, Elżbieta Trypka, Renata Wojtyńska, Jerzy Leszek, Marek Sąsiadek

Med Sci Monit 2010; 16(1): 5-10 :: ID: 880575

Abstract

Background: Accurate diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) is still a clinical problem. The aim of the study was to evaluate the usefulness of perfusion-weighted magnetic resonance (MR) imaging (PWI) and analysis of disturbances in the cerebral microcirculation in the differential diagnosis of AD and MCI.
Material/Methods: Thirty-four patients with AD (mean age, 71.6 years; Mini-Mental State Examination [MMSE] 18), 23 with MCI (mean age, 66.2 years; MMSE, 27), and 15 normal control subjects (mean age, 69 years; MMSE, 29.5) were enrolled in the study. All subjects underwent psychiatric examination and psychological tests. PWI was performed on a 1.5-T MR unit using dynamic susceptibility contrast (DSC) method (IV contrast, 0.3 mM/kg, 5 mL/s). Cerebral blood volume (CBV) measurements relative to cerebellum (rCBV) were assessed in both hippocampi, and temporoparietal and frontal association cortices as well as in the posterior cingulate region.
Results: Significantly lower rCBV values (P<.05) were found in temporoparietal, left frontal, and posterior cingulate cortices in AD patients compared with normal control subjects and in temporoparietal cortices and posterior cingulate region compared with MCI patients. In MCI patients, significantly lower rCBV values were noticed in the left frontal and posterior cingulate cortices compared with normal control subjects.
Conclusions: Our results confirm an important role of cerebral hypoperfusion, particularly in the posterior cingulate region, in the pathogenesis of AD and MCI. Assessment of rCBV, especially in the posterior cingulate cortex, can be useful in the differential diagnosis of AD and MCI.

Keywords: cerebral perfusion, magnetic resonance, Alzheimer’s Disease, Dementia

Add Comment 0 Comments

1504 0

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

08 Dec 2023 : Clinical Research  

Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...

Med Sci Monit In Press; DOI:  

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750