01 August 2010
Eosinophilic ulcer of the oral mucosa: Report of a child with CD30-negative cells in an infiltration on the lower lip
Malgorzata MisterskaBEF, Marian DmochowskiBEF, Joanna Szulczynska-GaborBEF, Hanna WalkowiakDF, Monika Bowszyc-DmochowskaADEFG, Janusz KaczmarekADEFG, Ryszard ZabaADEFGMed Sci Monit 2010; 16(8): CS95-99 :: ID: 881090
Abstract
Background: Eosinophilic ulcer of the oral mucosa (EUOM), also known as traumatic eosinophilic granuloma or Rida-Fede disease, is an uncommon, benign and self-limited lesion of the oral mucous membrane. The tongue is the most common location of EUOM, accounting for up to 60% of the cases, with the lateral and dorsal surfaces being principally affected. EUOM clinically manifests as a painful, nodular inflammatory infiltration, usually with ulceration. Characteristic histological findings consist of dense subepithelial, mixed inflammatory infiltration with numerous eosinophils. The etiology of the disease is unknown.
Case Report: We present a case of a 9-year-old boy, in whom a painful ulceration, nonresponding to typical antiviral and antibacterial treatment, occurred on the lower lip. The histological study revealed intact epithelium without the unequivocal signs of cellular atypia and a dense infiltrate in the stroma mainly composed of eosinophils and histiocytes with CD30-negative cells. The histological diagnosis of EUOM was given. A rapid resolution of the lesion was observed following biopsy.
Conclusions: EUOM, a relatively rare and benign disease, infrequently presenting as a lesion on lips, may cause diagnostic difficulties to dermatologists as well as to dental surgeons and ENT specialists. Biopsy is recommended to rule out malignant etiology and avoid overtreatment.
Keywords: Lip - pathology, Follow-Up Studies, Eosinophilic Granuloma - pathology, Eosinophilia - pathology, Child, Antigens, CD30 - metabolism, Mouth Mucosa - pathology, Ulcer - pathology
Editorial
01 November 2024 : Editorial
Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and PrognosisDOI: 10.12659/MSM.947038
Med Sci Monit 2024; 30:e947038
In Press
Clinical Research
Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylo...Med Sci Monit In Press; DOI: 10.12659/MSM.944469
Clinical Research
Comparative Analysis of Extended Curettage with Plate Fixation and Extended Curettage with Intramedullary N...Med Sci Monit In Press; DOI: 10.12659/MSM.945157
Clinical Research
Clinical Outcomes of Talus Bone Marrow Edema: Comparing Plaster Cast, Crutches, and Walking Boot TreatmentsMed Sci Monit In Press; DOI: 10.12659/MSM.946072
Review article
Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and PharmacokineticsMed Sci Monit In Press; DOI: 10.12659/MSM.945582
Most Viewed Current Articles
17 Jan 2024 : Review article 6,263,065
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,908,785
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 695,294
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 260,437
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074