Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 August 2010

Eosinophilic ulcer of the oral mucosa: Report of a child with CD30-negative cells in an infiltration on the lower lip

Malgorzata MisterskaBEF, Marian DmochowskiBEF, Joanna Szulczynska-GaborBEF, Hanna WalkowiakDF, Monika Bowszyc-DmochowskaADEFG, Janusz KaczmarekADEFG, Ryszard ZabaADEFG

Med Sci Monit 2010; 16(8): CS95-99 :: ID: 881090


Background: Eosinophilic ulcer of the oral mucosa (EUOM), also known as traumatic eosinophilic granuloma or Rida-Fede disease, is an uncommon, benign and self-limited lesion of the oral mucous membrane. The tongue is the most common location of EUOM, accounting for up to 60% of the cases, with the lateral and dorsal surfaces being principally affected. EUOM clinically manifests as a painful, nodular inflammatory infiltration, usually with ulceration. Characteristic histological findings consist of dense subepithelial, mixed inflammatory infiltration with numerous eosinophils. The etiology of the disease is unknown.
Case Report: We present a case of a 9-year-old boy, in whom a painful ulceration, nonresponding to typical antiviral and antibacterial treatment, occurred on the lower lip. The histological study revealed intact epithelium without the unequivocal signs of cellular atypia and a dense infiltrate in the stroma mainly composed of eosinophils and histiocytes with CD30-negative cells. The histological diagnosis of EUOM was given. A rapid resolution of the lesion was observed following biopsy.
Conclusions: EUOM, a relatively rare and benign disease, infrequently presenting as a lesion on lips, may cause diagnostic difficulties to dermatologists as well as to dental surgeons and ENT specialists. Biopsy is recommended to rule out malignant etiology and avoid overtreatment.

Keywords: Lip - pathology, Follow-Up Studies, Eosinophilic Granuloma - pathology, Eosinophilia - pathology, Child, Antigens, CD30 - metabolism, Mouth Mucosa - pathology, Ulcer - pathology

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

01 Feb 2024 : Review article  

Review of the Evaluation of Pulmonary Hypoplasia as an Important Determinant of Clinical Outcomes in Infant...

Med Sci Monit In Press; DOI: 10.12659/MSM.943259  


19 Feb 2024 : Clinical Research  

Diagnostic Accuracy of Ileocolic Artery and Vein Diameter for Acute Appendicitis

Med Sci Monit In Press; DOI: 10.12659/MSM.943846  

23 Feb 2024 : Clinical Research  

Early Mobilization in Pediatric Critical Care: Exploring the Gap Between Theory and Practice in Saudi Arabia

Med Sci Monit In Press; DOI: 10.12659/MSM.942467  

01 Feb 2024 : Review article  

Enhancing Patient Adherence to Newly-Prescribed Medicine for Chronic Diseases: A Comprehensive Review and C...

Med Sci Monit In Press; DOI: 10.12659/MSM.942923  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750