07 August 2010
Silk fibroin added to calcium phosphate cement to prevent severe cardiovascular complicationsTao DingDEF, Huilin YangAB, Mitchell MaltenfortCE, Ruijuan XieFG
Med Sci Monit 2010; 16(9): HY23-26 :: ID: 881112
As a bone cement in vertebroplasty and kyphoplasty, calcium phosphate cement (CPC) has several advantages over polymethylmethacrylate (PMMA) including biomcompatibility, biodegradability and osteoconductivity. However, its decay properties raise the risk of pulmonary embolism and consequent cardiovascular complications. Animal experiments have demonstrated that the disintegration of CPC forming more emboli, especially microemboli, causes more severe cardiovascular deterioration than PMMA. Current efforts focus on the incorporation of organic proteins or polymers into CPC to improve its stability in fluids, by enhancing the hydroxyapatite (HA) formation and reducing the fluid penetration. Silk fibroin (SF) can regular the mineralization process and bond with HA to form fibroin-HA nanocomposites with increased gelation properties. SF also has excellent biomechanical, biocompatible and biodegradable properties, and is convenient and inexpensive to produce. We hypothesize that silk fibroin can be used as an additive to improve the cohesion of CPC and decrease its risk of cardiovascular complications in its application in veterbroplasty/kyphoplasty.
Keywords: Pulmonary Embolism - etiology, Kyphoplasty - adverse effects, Fibroins - pharmacology, Cardiovascular Diseases - prevention & control, Calcium Phosphates - chemistry, Bone Cements - chemistry
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
01 Jun 2023 : Clinical ResearchRoot Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical ResearchInternal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease
Med Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical ResearchEffectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...
Med Sci Monit In Press; DOI: 10.12659/MSM.940187
01 Jun 2023 : Clinical ResearchInfluence of Insulin Resistance on Diabetes Nephropathy
Med Sci Monit In Press; DOI: 10.12659/MSM.939482
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952