Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2010

The divergent clinical presentations of transfusion-related acute lung injury illustrated by two case reports

Alexander P.J. VlaarABCDEF, Leendert PorcelijnBCDE, Ingeborgh H.M. van Rooijen-SchreursBE, Neubury Maxton LardyBCDE, Marie Jose KerstenBDE, Nicole P. JuffermansABCDEF

Med Sci Monit 2010; 16(10): CS129-134 :: ID: 881185


Background: Although the 2-event pathogenesis of transfusion-related (TR) acute lung injury (ALI) has been accepted as an explanatory model, case reports classically describe patients without other risk factors for ALI. Patients who exhibit another risk factor for the onset of ALI may be neglected as having TRALI, which contributes to underreporting.
Case Report: Two cases of TRALI are reported. The first case is a patient with a hematologic malignancy who experienced ALI within 1 hour after a transfusion of concentrated platelets (PLT), with no other risk factor for ALI present. The second case is a patient with severe sepsis with multiorgan failure who received multiple transfusions during a laparotomy and exhibited ALI perioperatively. The implicated blood components originated from female donors in both cases. Analysis of the plasma of the PLT donor in the first case revealed HLA class I and II antibodies directed against the patient’s antigen. Analysis of the plasma of the fresh-frozen plasma donor in the second case did not reveal antibodies using the techniques available at that time. However, after involvement of this donor in a TRALI reaction in another recipient, HLA II antibodies directed against the antigen of the recipient were detected in the newly available single antigen Luminex technique.
Conclusions: The 2 cases illustrate that TRALI can occur both in the absence and in the presence of another ALI risk factor. Awareness should be increased that all patients exhibiting ALI within 6 hours of a blood transfusion, including possible TRALI, should be reported to the blood bank.

Keywords: perioperative period, Plasma - immunology, HLA Antigens - immunology, Blood Transfusion - adverse effects, Blood Donors, Antibodies - immunology, Acute Lung Injury - physiopathology, Platelet Transfusion - adverse effects, Risk Factors, Time Factors

Add Comment 0 Comments

848 4


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750