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01 February 2011

Lack of effect of the CD14 promoter gene C-159T polymorphism on nutritional status parameters in hemodialysis patients

Agnieszka SerwackaBCDE, Tomasz ProtaziukBCDE, Malgorzata ZagozdaCD, Anna-Maria PopowB, Maciej KierzkiewiczB, Jacek ManitiusB, Michal MysliwiecB, Dorota DaniewskaB, Sewer GolebiewskiB, Alicja Rydzewska-RosolowskaBDEF, Mariusz FlisinskiB, Krystyna StepienB, Grazyna RydzewskaACDEG, Waldemar L. OlszewskiADG, Andrzej RydzewskiACDEFG

DOI: 10.12659/MSM.881397

Med Sci Monit 2011; 17(2): CR117-121


Background: CD14 is a membrane glycoprotein that acts as a co-receptor for the detection of bacterial lipopolysaccharide (LPS). Mutual interaction between CD14 and LPS plays an important role in the innate immune system. Increased serum soluble CD14 levels have been described in hemodialysis (HD) patients, and linked to increased mortality risk, inflammation and protein-energy wasting. The expression of CD14 may be influenced by CD14 promoter gene C-159T polymorphism.
This study aimed to clarify the possible association between CD14 promoter gene C-159T polymorphism and nutritional status in hemodialysis patients.
Material/Methods: The study population consisted of 185 (104 males; 81 females) long-term HD patients treated in 5 dialysis centers. The control group consisted of 112 apparently healthy volunteers (32 males and 80 females). Nutritional status was assessed using a modified SGA scale, and anthropometric methods (BMI, WHR, waist, hip and mid-arm circumferences, biceps, triceps, subocular and subscapular skinfolds). Biochemical parameters evaluated included: CRP, albumin, creatinine, urea, cholesterol, triglycerides and TIBC. CD14 promoter gene C-159T polymorphism was determined by restriction fragment length polymorphism, after digestion of the PCR product with Hae III restriction endonuclease.
Results: Genotype and allele frequencies were similar to controls and compliant with Hardy-Weinberg equilibrium. No between-group differences were detected in measured variables with the exception of lower triglyceride levels in carriers of C allele in comparison to TT genotype.
Conclusions: CD14 promoter gene C-159T polymorphism does not seem to be associated with nutritional status parameters in HD patients. It does seem, however, to influence triglyceride blood levels.

Keywords: Polymorphism, Single Nucleotide - genetics, Nutritional Status - genetics, Genotype, Gene Frequency - genetics, Antigens, CD14 - genetics, Alleles, Promoter Regions, Genetic, Renal Dialysis

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Medical Science Monitor eISSN: 1643-3750