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24 July 2014 : Original article  

Toxic Effects of Chronic Mercury Exposure on the Retinal Nerve Fiber Layer and Macular and Choroidal Thickness in Industrial Mercury Battery Workers

Metin EkinciACE, Erdinç CeylanAB, Sadullah KeleşCF, Halil Hüseyin ÇağatayDF, Aytekin ApilBE, Burak TanyıldızBD, Gunay UludagCF

DOI: 10.12659/MSM.890756

Med Sci Monit 2014; 20:1284-1290


BACKGROUND: The aim of this study was to evaluate the toxic effects of mercury on retinal nerve fiber layer thickness (RNFLT), macular thickness (MT), and choroidal thickness (CT) by using spectral-domain optical coherence tomography (SD-OCT) in battery industry workers who had been chronically exposed to mercury.

MATERIAL AND METHODS: Battery factory workers (n=31) and healthy non-factory employee controls (n=15) participated in the study. Participants were divided into 3 groups: Group 1 (n=15) was factory workers who had worked for more than 5 years in a mercury battery factory; Group 2 (n=16) was factory worker who had worked for less than 5 years in a mercury battery factory; and Group 3 (n=15) was healthy non-employees. Systemic symptoms were recorded. Ophthalmic examination included best-corrected visual acuity test, color vision test, full ophthalmologic examination, and SD-OCT of the RNLF, macula, and choroid. To determine mercury exposure, venous blood samples were collected and mercury levels were assessed.

RESULTS: In our study group the most common systemic symptoms were insomnia (67.7%) and fatigue (67.7%). There were no significant differences between Group 1 and Group 2, but there were significant differences between Group 3 and both Group 1 and Group 2 in best-corrected visual acuity values (1=2<3), color vision scores, blood mercury levels, and duration (mean ±SD, range) of mercury exposure(1>2>3). OCT values of RNFLTs, MTs, and CTs of all 3 groups were statistically different from each another (1<2<3).

CONCLUSIONS: SD-OCT can be useful for evaluating the toxic effects of chronic exposure to mercury.

Keywords: Color Vision - drug effects, Choroid - pathology, Macula Lutea - pathology, Manufacturing Industry, Mercury - toxicity, Nerve Fibers - drug effects, Occupational Exposure - adverse effects, Retina - drug effects, Time Factors, Tomography, Optical Coherence - methods, Turkey, Visual Acuity - drug effects

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Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750