19 December 2014 : Review article
In Search of Memory Tests Equivalent for Experiments on Animals and HumansAndrzej BrodziakABCDEF, Estera KołatCDF, Alicja Różyk-MyrtaBDFG
Med Sci Monit 2014; 20:2733-2739
Older people often exhibit memory impairments. Contemporary demographic trends cause aging of the society. In this situation, it is important to conduct clinical trials of drugs and use training methods to improve memory capacity. Development of new memory tests requires experiments on animals and then clinical trials in humans. Therefore, we decided to review the assessment methods and search for tests that evaluate analogous cognitive processes in animals and humans. This review has enabled us to propose 2 pairs of tests of the efficiency of working memory capacity in animals and humans. We propose a basic set of methods for complex clinical trials of drugs and training methods to improve memory, consisting of 2 pairs of tests: 1) the Novel Object Recognition Test – Sternberg Item Recognition Test and 2) the Object-Location Test – Visuospatial Memory Test. We postulate that further investigations of methods that are equivalent in animals experiments and observations performed on humans are necessary.
Keywords: Memory - physiology, Neuropsychological Tests, Research Personnel, Statistics as Topic
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