24 October 2014 : Original article
Impact of Acoustic Radiation Force Impulse Imaging in Clinical Practice of Patients after Orthotopic Liver Transplantation
Dane WildnerABCDEF, Deike StrobelBDEF, Peter C. KonturekDEF, Rüdiger S. GörtzCDEF, Roland S. CronerBDE, Markus F. NeurathDE, Steffen ZopfABCDEFDOI: 10.12659/MSM.891126
Med Sci Monit 2014; 20:2027-2035
Abstract
BACKGROUND: Acoustic radiation force impulse (ARFI) elastography is a reliable diagnostic device for quantitative non-invasive assessment of liver fibrosis in patients with chronic liver disease. The aim of our prospective study was to evaluate the impact of ARFI in patients after orthotopic liver transplantation (OLT). Therefore, we compared ARFI shear wave velocities with clinical features, non-invasive markers, and the histology of patients following OLT.
MATERIAL AND METHODS: Post-transplant patients underwent a clinical examination and blood samples were taken. B-mode and Doppler ultrasound (US) of the portal vein and the hepatic artery were performed. Subsequently, a minimum of 10 valid ARFI values were measured in the left and right liver lobe. Liver biopsy was performed if indicated.
RESULTS: Between May 2012 and May 2014, 58 Patients after OLT were included in the prospective study. Laboratory markers and aspartate aminotransferase-to-platelet ratio index (APRI) correlated with ARFI values (r=0.44, p<0.001). The histological (n=22) fibrosis score (Ludwig) was significantly correlated with the ARFI of the biopsy site (r=0.55, p=0.008). The mean shear-wave velocities were significantly increased in advanced fibrosis (F≤2 1.57±0.57 m/s; F≥3 2.85±0.66 m/s; p<0.001), obstructive cholestasis and active viral hepatitis. The area under the receiver operating characteristic (AUROC) curves for the accuracy of ARFI were 74% (F≥1), 73% (F≥2), 93% (F≥3), and 80% (=F4).
CONCLUSIONS: ARFI elastography correlates well with laboratory values and with noninvasive and invasive markers of fibrosis in patients after OLT. In this regard, elevated ARFI-velocities should be interpreted with caution in the context of obstructive cholestasis and active viral disease.
Keywords: Acoustics, Aspartate Aminotransferases - blood, Biopsy, Liver - pathology, Liver Transplantation
876 1
Editorial
01 September 2023 : Editorial
Editorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2DOI: 10.12659/MSM.942244
Med Sci Monit 2023; 29:e942244
In Press
22 Sep 2023 : Clinical Research
Comparative Analysis of Symptomatology in Hospitalized Children with RSV, COVID-19, and Influenza InfectionsMed Sci Monit In Press; DOI: 10.12659/MSM.941229
21 Sep 2023 : Clinical Research
The Impact of Implementing the Vortex Approach on Airway Management Performance in Stressed Medical Student...Med Sci Monit In Press; DOI: 10.12659/MSM.940372
20 Sep 2023 : Clinical Research
Changes in Upper Airway Anatomy Following Orthodontic Treatment for Malocclusion: A Comparative Retrospecti...Med Sci Monit In Press; DOI: 10.12659/MSM.941749
20 Sep 2023 : Database Analysis
Comparative Finite Element Analysis of Endocrowns and Traditional Restorations for Endodontically Treated M...Med Sci Monit In Press; DOI: 10.12659/MSM.941314
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952