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13 March 2015 : Clinical Research  

Serum Galectin-3 as a Potential Marker for Gastric Cancer

Daye ChengADE, Bin LiangBC, Yunhui LiCF

DOI: 10.12659/MSM.892386

Med Sci Monit 2015; 21:755-760


BACKGROUND: The identification of cancer biomarkers can advance the possibility for early detection and better monitoring of tumor progression. The aim of this study was to assess the diagnostic and prognostic value of serum galectin-3(Gal-3) in patients with gastric cancer (GC).

MATERIAL AND METHODS: We measured serum Gal-3 levels using ELISA method in 87 patients with GC, 53 patients with benign gastric lesions, and 51 healthy controls.

RESULTS: Serum levels of Gal-3 in patients with GC were significantly higher than those in benign disease patients and healthy controls (P<0.001), but no difference was found between benign disease patients and healthy controls (P=0.635). Additionally, serum Gal-3 level was associated with lymph node metastasis (P=0.001) and distant metastasis (P<0.001), whereas it was not related to gender (P=0.204), age (P=0.269), tumor size (P=0.399), location (P=0.715), TNM stage (P=0.385), differentiation (P=0.135), or invasion depth (P=0.273). The Kaplan-Meier survival analysis revealed that overall survival rates in patients with high Gal-3 levels were not significantly different that those with low Gal-3 levels (P=0.099).

CONCLUSIONS: Results of the current study suggests that serum Gal-3 represents a potential diagnostic marker for patients with GC, and may be an adjunct to determine the individual prognosis of these patients.

Keywords: Biomarkers, Tumor - blood, Case-Control Studies, Galectin 3 - blood, Kaplan-Meier Estimate, ROC Curve



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Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750