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02 June 2015 : Clinical Research

[Retracted: 07 Jan 2016] Correlation Between High-Density Lipoprotein and Monocyte Subsets in Patients with Stable Coronary Heart Disease

Shaoyan JiangABC, Dan LiDE, Jian LiFG, Yi AnEFG

DOI: 10.12659/MSM.894485

Med Sci Monit 2015; 21:3129-3135

In the article entitled, "Correlation Between High-Density Lipoprotein and Monocyte Subsets in Patients with Stable Coronary Heart Disease" which was published in Medical Science Monitor 2015;21: 3129-3135, sections in the text have been directly copied from a previously published article, entitled, "Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease", Krychtiuk KA, Kastl SP, Pfaffenberger S, Pongratz T, Hofbauer SL, Wonnerth A, Katsaros KM, Goliasch G, Gaspar L, Huber K, Maurer G, Dostal E, Oravec S, Wojta J, Speidl WS  in Atherosclerosis 2014 Dec;237(2):589-96. Thus owing to duplicity of text, the article is being retracted. Reference: 1. Shaoyan Jiang, Dan Li, Jian Li, Yi An Correlation Between High-Density Lipoprotein and Monocyte Subsets in Patients with Stable Coronary Heart Disease Medical Science Monitor 2015;21: 3129-3135 DOI 10.12659/MSM.894485

Abstract

BACKGROUND: High-density lipoprotein (HDL) consists of heterogeneous particles with a variety of structures and functions. Its role in atherosclerosis has been gradually recognized. Studies have shown dysfunction of small HDL in patients with coronary artery disease (CAD). Monocytes play an important role in atherosclerosis, which can be divided into 3 subgroups based on the expression of surface markers CD14 and CD16. This study aimed to investigate the association between HDL and monocyte subsets in CAD patients. 

MATERIAL AND METHODS: A total of 90 patients with stable CAD were selected in this study. Monocytes were divided into classical monocytes (CM, CD14++CD16-), intermediate monocytes (IM, CD14++CD16+), and non-classical monocytes (NCM, CD14+CD16++). HDL components in serum were determined by high-resolution polyacrylamide gel electrophoresis (detected by Quantimetrix HDL Lipoprint system, referring to HDL subfractions analysis: A new laboratory diagnostic assay for patients with cardiovascular diseases and dyslipoproteinemia). 

RESULTS: Serum level of small HDL was positively correlated with circulating proinflammatory NCM (r=0.30; p=0.004), negatively correlated with CM, and not correlated with IM. We also found that disease severity was not associated with diabetes mellitus, glycosylated hemoglobin, hypertension, smoking history, or statin dosage. 

CONCLUSIONS: Our study confirmed that small HDL level is associated with an increase in NCM and a decrease in CM, suggesting the proinflammatory relationship between small HDL and intrinsic immune function during the progression of stable CAD. 

Keywords: Hypoalphalipoproteinemias, Intracranial Arteriosclerosis, Ribosome Subunits, Small, Archaeal

Retraction note

Med Sci Monit 2016; 22:415-415     https://medscimonit.com/abstract/index/idArt/897961
 
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750