17 October 2016 : Clinical Research
Early and Late Acute Kidney Injury in Severely Burned PatientsWojciech WitkowskiACDEFG, Marek KaweckiACDFG, Agnieszka Surowiecka- PastewkaBCDEF, Wojciech KlimmBCDEF, Katarzyna SzamotulskaCDE, Stanisław NiemczykACDEFG
Med Sci Monit 2016; 22:3755-3763
BACKGROUND: This study evaluated factors influencing early and late occurrence of AKI in severely burned patients and assessed the relationship between time of occurrence of AKI and mortality of AKI patients.
MATERIAL AND METHODS: Renal function was evaluated at 3 time points: at admission, at the critical point or middle point of hospitalization, and at the endpoint for which death or a discharge from the center was considered. AKI criteria were: decrease in GFR of less than 60 ml/min at admission, decrease in GFR of more than 75% compared to baseline, and decrease in the daily diuresis of less than 500 ml/24 h.
RESULTS: At admission, 15.1% of the patients had eGFR <60 ml/min. AKI occurred in 38.5% of cases. The occurrence of AKI was associated with: elderly age (p<0.001), female sex (p=0.017), overweight and obesity (p=0.055); extent and depth of burns, respiratory failure, low protein concentration (for all p<0.001), low blood pressure (p=0.014), and high WBC (p=0.010). Early AKI was detected in 28% of patients. Mortality was 100% with the initial GFR ≥60, 100% with the initial GFR <60 and early deterioration of renal function, 80% with the initial GFR <60 and late worsening, and 60% with the initial GFR <60 and no worsening. Late AKI was observed in 10% of patients and mortality in this group was 79.2%. Mortality in the entire group with AKI was 88.0% versus 24.5%.
CONCLUSIONS: The frequent occurrence of AKI, especially early, worsens the prognosis for survival. Assessment of renal function should be included in the prognostic scales for burned patients.
Keywords: Acute Kidney Injury - physiopathology, Burns - physiopathology, Creatinine - blood, Glomerular Filtration Rate, Hospitalization, Patient Discharge, Prognosis, Risk Factors
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