09 May 2016 : Clinical Research
Expression of Chemokine XCL2 and CX3CL1 in Lung CancerBing ZhouCD, Heyun XuABC, Kewei NiDE, Xuming NiEF, Jian ShenFG
Med Sci Monit 2016; 22:1560-1565
BACKGROUND: Chemokines are a family of small proteins secreted by cells with chemotactic activity, and they play important roles in cell adhesion. However, the expression of chemokine XCL2 and CX3CL1 in lung cancers in different pathological stages remains unclear.
MATERIAL AND METHODS: XCL2 and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The relative expression of both chemokines in lung cancers in different pathological stages was compared by immunohistochemical assay.
RESULTS: The relative expression level of XCL2 and CX3CL1 in lung cancer was significantly higher compared with adjacent normal tissues (P<0.001). The expression level of both chemokines was significantly increased with higher pathological stages, as indicated by immunohistochemical assay (P<0.05 or P <0.001). Their expression level in cancers with higher numbers of metastatic lymph nodes was also significantly increased compared with cancers with lower numbers of metastatic lymph nodes (P<0.05 or P<0.001).
CONCLUSIONS: The expression of XCL2 and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer.
Keywords: Cell Adhesion - physiology, Chemokine CX3CL1 - metabolism, Chemokines, C - metabolism, Gene Expression Profiling, Lung Neoplasms - pathology, Neoplasm Staging, RNA, Messenger - metabolism, Real-Time Polymerase Chain Reaction
01 March 2023 : EditorialEditorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic
Med Sci Monit 2023; 29:e939968
09 February 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical ResearchRetrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...
Med Sci Monit 2022; 28:e938647
24 Mar 2023 : Database AnalysisCauses of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis
Med Sci Monit In Press; DOI: 10.12659/MSM.939848
22 Mar 2023 : Special reportOne Year On: Poland’s Public Health Initiatives and National Response to Millions of Refugees from Ukraine
Med Sci Monit In Press; DOI: 10.12659/MSM.940223
22 Mar 2023 : Clinical ResearchValue of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study
Med Sci Monit In Press; DOI: 10.12659/MSM.940163
21 Mar 2023 : Clinical ResearchEfficacy of Direct Anterior Approach Versus Posterior Lateral Approach for Total Hip Replacement in Patient...
Med Sci Monit In Press; DOI: 10.12659/MSM.939682
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952