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30 April 2016 : Meta-Analysis  

Association Between Isolated Single Umbilical Artery and Perinatal Outcomes: A Meta-Analysis

Yajuan XuA, Lidan RenBCE, Shanshan ZhaiCE, Xiaohua LuoE, Teng HongB, Rui LiuB, Limin RanB, Yingying ZhangB

DOI: 10.12659/MSM.897324

Med Sci Monit 2016; 22:1451-1459


BACKGROUND: To evaluate the association between the isolated single umbilical artery (iSUA) and perinatal outcomes, including pregnancy outcomes and perinatal complications.

MATERIAL AND METHODS: We performed a meta-analysis of 15 eligible studies regarding the relationship between the iSUA and perinatal outcomes, including gestational age at delivery, nuchal cord, placental weight, small for gestational age (SGA), oligohydramnios, polyhydramnios, pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), preeclampsia, and perinatal mortality. The overall odds ratios (OR) or standardized mean difference (SMD) were calculated.

RESULTS: The occurrence of nuchal cord was not found to be different between an iSUA and a three-vessel cord (TVC) fetus. For perinatal complications, the SGA, oligohydramnios, polyhydramnios, GDM, and perinatal mortality showed dramatic difference between women with an iSUA and women with a TVC fetus, which implied that the presence of iSUA significantly increased the risk of perinatal complications. For other perinatal complications, such as PIH and preeclampsia, no significant association was detected.

CONCLUSIONS: Our meta-analysis suggests that the presence of iSUA would increase the risk of perinatal complications such as SGA, oligohydramnios, polyhydramnios, GDM, and perinatal mortality. Therefore, pregnant women with an iSUA fetus have poorer perinatal outcomes and more attention should be given to the management of their pregnancy compared to women with a TVC fetus.

Keywords: Gestational Age, Pregnancy, Pregnancy Outcome, Publication Bias, Single Umbilical Artery - pathology



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Ana Luisa Ordóñez-Vázquez, Sofía Murúa Beltrán-Gall, Shreya C. Pal, Nahum Méndez-Sánchez
Liver Research Unit, Medica Sur Clinic Foundation, Mexico City, Mexico

DOI: 10.12659/MSM.938365

Med Sci Monit 2022; 28:e938365


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750