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06 November 2016 : Clinical Research  

Effect of Splenectomy Combined with Resection for Gastric Carcinoma on Patient Prognosis

Dun PanAB, Hui ChenBF, Liang-qing LiABCEG, Zong-fang LiCD

DOI: 10.12659/MSM.897842

Med Sci Monit 2016; 22:4205-4209

Abstract

BACKGROUND: For patients with stage IV gastric cancer, it is unclear whether splenectomy combined with palliative surgery is needed to reduce tumor load and relieve symptoms. The objective of the present study was to investigate the effect of splenectomy combined with palliative resection for stage IV gastric carcinoma on immunological dysfunction and patient prognosis.

MATERIAL AND METHODS: We retrospectively analyzed medical records of 106 stage IV gastric cancer patients who underwent palliative surgery; of these, 49 patients were treated with palliative resection for gastric carcinoma combined with splenectomy, while the other 57 patients retained their spleens. The immunologic function and prognosis in these 2 groups were examined and compared.

RESULTS: The immune function of patients in the group that retained their spleens was better later in the postoperative course than in the resection group. The groups did not show statistically significant differences in postoperative infectious complications, median survival time, and survival rate; however, the average postoperative hospitalization time of patients in the retained group was significantly shorter.

CONCLUSIONS: Splenectomy combined with gastric cancer resection did not improve the prognosis of the patients; patients who retained their spleens had faster recovery and improved immune function. However, whether retaining the spleen is an independent factor improving the prognosis needs further investigation.

Keywords: Postoperative Complications - etiology, Splenectomy - adverse effects, Stomach Neoplasms - surgery

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750