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02 December 2016 : Clinical Research  

Elevated Fasting Plasma Glucose before Liver Transplantation is Associated with Lower Post-Transplant Survival

Emi Katsura1B, Tatsuki Ichikawa2ABCDEF*, Naota Taura1B, Hisamitsu Miyaaki1B, Satoshi Miuma1B, Hidetaka Shibata1B, Takuya Honda1B, Masaaki Hidaka3B, Akihiko Soyama3B, Fuminao Takeshima1B, Susumu Eguchi3F, Kazuhiko Nakao1D

DOI: 10.12659/MSM.897925

Med Sci Monit 2016; 22:4707-4715

Abstract

BACKGROUND: The risk of liver cirrhosis is higher among individuals with diabetes mellitus, and a cirrhotic patient with diabetes may have a poorer prognosis after liver transplantation compared to a patient without diabetes. Thus, we evaluated whether fasting plasma glucose prior to receiving a liver transplant was a prognostic factor for post-transplant survival.

MATERIAL AND METHODS: Ninety-one patients received a living donor liver transplant between November 2005 and December 2012. Patients were considered diabetic if they were prescribed diabetes medications or had impaired glucose tolerance as measured by an oral glucose tolerance test. Each patient was monitored through December 31, 2013, to evaluate prognosis.

RESULTS: Fasting plasma glucose of at least 100 mg/dL significantly decreased survival following transplant (52% in the high FPG group compared to 78% in the control group, p=0.04), while postprandial hyperglycemia had no effect on survival. Additionally, overall mortality and the incidence of vascular disease were significantly higher among patients with uncontrolled plasma glucose. Impaired fasting plasma glucose was significantly and inversely associated with overall survival in the univariate and multivariate analyses, while creatinine (at least 1 mg/dL) was inversely associated with survival in the univariate analysis.

CONCLUSIONS: Elevated fasting plasma glucose prior to liver transplantation was inversely associated with post-transplant survival. This effect may be due to underlying microangiopathy as a result of uncontrolled diabetes before transplantation. Our data demonstrated the importance of controlled blood glucose prior to liver transplantation.

Keywords: Biomarkers - blood, Blood Glucose - metabolism, Diabetes Complications - blood, Diabetes Mellitus - blood, Fasting - blood, Glucose Tolerance Test, Graft Survival, Hyperglycemia - drug therapy, Liver Cirrhosis - surgery, Liver Transplantation - methods, Prognosis, Risk Factors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750