29 January 2017 : Animal Research
General Toxicity and Antifungal Activity of a New Dental Gel with Essential Oil from Abies Sibirica L.
Aurelija Noreikaitė1DEF*, Rizvangul Ayupova2BE, Elmira Satbayeva3CE, Aida Seitaliyeva3B, Marzhan Amirkulova3CD, Guram Pichkhadze3D, Ubaidilla Datkhayev4B, Edgaras Stankevičius1ADOI: 10.12659/MSM.898630
Med Sci Monit 2017; 23:521-527
Abstract
BACKGROUND: The aim of this study was to analyze the antifungal activity and the general toxicity of a new dental gel containing essential oil from the tree Abies sibirica L., which grows in the Republic of Kazakhstan.
MATERIAL AND METHODS: The essential oil from Abies sibirica L. was obtained by microwave heating method using the STARTE Microwave Extraction System. Adjutants used to prepare the oil were carbomer 974P, glycerin, polysorbate 80, xylitol, triethanolamine, and purified water, all allowed for medical usage. The antifungal activity of the essential oil was assessed by monitoring the optical density of Candida albicans in a microplate reader. The safety was determined by analyzing the acute and subacute toxicity.
RESULTS: The essential oil obtained by the microwave heating method revealed a higher antifungal activity in comparison with the essential oil obtained by the steam distillation method. No obvious changes were detected in guinea pigs following cutaneous application of the gel. Enteral administration of the essential oil caused minimal functional and histological changes in mice after 4 weeks. The new harmless dental gel containing pine oil from Abies sibirica L. was provided for the purposes of this particular clinical research.
CONCLUSIONS: The high antifungal activity of the gel is the basis for more in-depth studies on its safety and pharmacological activity.
Keywords: Administration, Buccal, Abies - chemistry, Antifungal Agents - toxicity, Candida albicans - drug effects, Dental Materials - toxicity, Gels - toxicity, Guinea Pigs, Microbial Sensitivity Tests, Oils, Volatile - toxicity
Editorial
01 February 2025 : Editorial
Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-SmokersDOI: 10.12659/MSM.948255
Med Sci Monit 2025; 31:e948255
In Press
Clinical Research
Evaluation of Knowledge, Attitudes, and Practices Toward Thyroid Nodules in 456 Patients with Thyroid NodulesMed Sci Monit In Press; DOI: 10.12659/MSM.945732
Review article
Comparative Efficacy of 3D-Printed Insoles in Managing Common Foot Conditions: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.947252
Clinical Research
Correlation Descriptive Study on Nurses' Professional Values and Job Satisfaction and the Ethical Climate o...Med Sci Monit In Press; DOI: 10.12659/MSM.945639
Clinical Research
Pre- and Post-Surgical MRI Analysis of Levator Ani in Pelvic Organ Prolapse Patients: A Single-Center StudyMed Sci Monit In Press; DOI: 10.12659/MSM.945993
Most Viewed Current Articles
17 Jan 2024 : Review article 6,967,723
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 701,731
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Mar 2024 : Editorial 25,246
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...DOI :10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
28 Jan 2024 : Review article 19,861
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and FutureDOI :10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912