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05 May 2016 : Clinical Research  

Incarcerated Inguinal Hernia Mesh Repair: Effect on Testicular Blood Flow and Sperm Autoimmunity

Dragan KrnićABCDEF, Nikica DružijanićAD, Ivana ŠtulaABCDF, Vesna ČapkunBCDE, Duška KrnićBDEF

DOI: 10.12659/MSM.898727

Med Sci Monit 2016; 22:1524-1533

Abstract

BACKGROUND: The aim of our study was to determine an influence of incarcerated inguinal hernia mesh repair on testicular circulation and to investigate consequent sperm autoimmunity as a possible reason for infertility.

MATERIAL AND METHODS: This prospective study was performed over a 3-year period, and 50 male patients were included; 25 of these patients underwent elective open mesh hernia repair (Group I). Group II consisted of 25 patients who had surgery for incarcerated inguinal hernia. Doppler ultrasound evaluation of the testicular blood flow and blood samplings for antisperm antibodies (ASA) was performed in all patients before the surgery, on the second day, and 5 months after. Main outcome ultrasound measures were resistive index (RI) and pulsative index (PI), as their values are inversely proportional to testicular blood flow.

RESULTS: In Group I, RI, and PI temporarily increased after surgery and then returned to basal values in the late postoperative period. Friedman analysis showed a significant difference in RI and PI for all measurements in Group II (p<0.05), with a significant decrease between the preoperative, early, and late postoperative periods. All final values were within reference range, including ASA, despite significant increase of ASA in the late postoperative period.

CONCLUSIONS: Although statistically significant differences in values of testicular flow parameters and immunologic sensitization in observed time, final values remained within the reference ranges in all patients. Our results suggest that the polypropylene mesh probably does not cause any clinically significant effect on testicular flow and immunologic response in both groups of patients.

Keywords: Antibodies - immunology, Aged, 80 and over, Autoimmunity, Diastole, Elective Surgical Procedures, Emergencies, Hernia, Inguinal - surgery, Postoperative Care, Pulse, Regional Blood Flow, Spermatozoa - immunology, Surgical Mesh, Systole, Testis - physiopathology, Wound Healing

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750