15 January 2017 : Animal Research
Med Sci Monit 2017; 23:258-265
BACKGROUND: Leptin plays a crucial role in bone metabolism, and its level is related to bone callus formation in the fracture repair process. The objective of this study was to evaluate the effect of recombinant leptin on the healing process of femoral fractures in rats.
MATERIAL AND METHODS: Forty-eight male Sprague Dawley (SD) rats with an average body weight of 389 g (range: 376–398 g) and an average age of 10 weeks were included in this animal research, and all rats were randomly divided into two major groups. Then standardized femur fracture models were implemented in all SD rats. Rats in the control group were treated with only 0.5 mL of physiological saline, and rats in the experimental group were treated with recombinant leptin 5 μg/kg/d along with the same 0.5 mL of physiological saline for 42 days intraperitoneally. At the same time, each major group was evenly divided into three parallel subgroups for each parallel bone evaluation separately at the second, fourth, and sixth weeks. Each subgroup included eight rats.
RESULTS: The total radiological evaluation results showed that the healing progress of femoral fracture in the experimental group was superior to that in the control group from the fourth week. At the sixth week, experimental group rats began to present significantly better femoral fracture healing progress than that of the control group rats. Results of biomechanics show the ultimate load (N) and deflection ultimate load (mm) of the experimental group rats was significantly increased compared with that of the control group rats from the fourth week.
CONCLUSIONS: Our results suggest that leptin may have a positive effect on SD rat femur fracture healing.
Keywords: Femur, Fracture Healing, Leptin
01 February 2024 : EditorialEditorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise
Med Sci Monit 2024; 30:e943911
02 Jan 2024 : Clinical ResearchUrinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion
Med Sci Monit In Press; DOI: 10.12659/MSM.942819
29 Dec 2023 : Clinical ResearchPerformance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...
Med Sci Monit In Press; DOI: 10.12659/MSM.942747
08 Jan 2024 : Review articleReview of Approaches to the Management of Vertical Dental Root Fractures and Tooth Preservation
Med Sci Monit In Press; DOI: 10.12659/MSM.943100
Most Viewed Current Articles
16 May 2023 : Clinical ResearchElectrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review articleVaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990