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12 December 2016 : Clinical Research  

Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population

Gao-Ming Zhang1BCF, Xu-Xiao Guo2ABCDEF, Xiao-Bo Ma1BDF, Guo-Ming Zhang1ABCDEFG*

DOI: 10.12659/MSM.901861

Med Sci Monit 2016; 22:4875-4880


BACKGROUND: The aim of this study was to calculate 95% reference intervals and double-sided limits of serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI EP28-A3 guideline.

MATERIAL AND METHODS: Serum AFP and CEA values were measured in samples from 26 000 healthy subjects in the Shuyang area receiving general health checkups. The 95% reference intervals and upper limits were calculated by using MedCalc.

RESULTS: We provided continuous reference intervals from 20 years old to 90 years old for AFP and CEA. The reference intervals were: AFP, 1.31–7.89 ng/ml (males) and 1.01–7.10 ng/ml (females); CEA, 0.51–4.86 ng/ml (males) and 0.35–3.45ng/ml (females). AFP and CEA were significantly positively correlated with age in both males (r=0.196 and r=0.198) and females (r=0.121 and r=0.197).

CONCLUSIONS: Different races or populations and different detection systems may result in different reference intervals for AFP and CEA. Continuous reference intervals of age changes are more accurate than age groups.

Keywords: alpha-Fetoproteins, Carcinoembryonic Antigen, Reference Values

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01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750