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22 July 2017 : Laboratory Research  

Preparing Platelet-Rich Plasma with Whole Blood Harvested Intraoperatively During Spinal Fusion

Bin Shen1D, Zheng Zhang2D, Ning-Feng Zhou1ABCDE*, Yu-Feng Huang1C, Yu-Jie Bao3F, De-Sheng Wu1F, Ya-Dong Zhang1EF

DOI: 10.12659/MSM.902025

Med Sci Monit 2017; 23:3578-3584

Abstract

BACKGROUND: Platelet-rich plasma (PRP) has gained growing popularity in use in spinal fusion procedures in the last decade. Substantial intraoperative blood loss is frequently accompanied with spinal fusion, and it is unknown whether blood harvested intraoperatively qualifies for PRP preparation.

MATERIAL AND METHODS: Whole blood was harvested intraoperatively and venous blood was collected by venipuncture. Then, we investigated the platelet concentrations in whole blood and PRP, the concentration of growth factors in PRP, and the effects of PRP on the proliferation and viability of human bone marrow-derived mesenchymal stem cells (HBMSCs).

RESULTS: Our results revealed that intraoperatively harvested whole blood and whole blood collected by venipuncture were similar in platelet concentration. In addition, PRP formulations prepared from both kinds of whole blood were similar in concentration of platelet and growth factors. Additional analysis showed that the similar concentrations of growth factors resulted from the similar platelet concentrations of whole blood and PRP between the two groups. Moreover, these two kinds of PRP formulations had similar effects on promoting cell proliferation and enhancing cell viability.

CONCLUSIONS: Therefore, intraoperatively harvested whole blood may be a potential option for preparing PRP spinal fusion.

Keywords: Osteoarthritis, Spine, platelet-rich plasma

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750