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14 December 2016 : Clinical Research  

In-Depth Analysis on Influencing Factors of Adjacent Segment Degeneration After Cervical Fusion

Chaojie Yu12ABCDEF, Xiaoping Mu1ABCDEF, Jianxun Wei1CDE, Ye Chu1BE, Bin Liang1ACEG*

DOI: 10.12659/MSM.902179

Med Sci Monit 2016; 22:4902-4910

Abstract

BACKGROUND: To explore the related influencing factors of adjacent segment degeneration (ASD) after cervical discectomy and fusion (ACDF).

MATERIAL AND METHODS: A retrospective analysis of 263 patients who underwent ACDF was carried out. Cervical x-ray and magnetic resonance imaging (MRI) were required before operation, after operation, and at the last follow-up. General information and some radiographic parameters of all patients were measured and recorded. According to the imaging data, patients were put into one of two groups: non-ASD group and ASD group. The differences between the two groups were compared by t-test and χ²-test, and the related influencing factors of ASD were analyzed by logistic regression.

RESULTS: In all, 138 patients had imaging ASD. Comparing the age, the postoperative cervical arc chord distance (po-CACD), and the plate to disc distance (PDD) of the two groups, differences were statistically significant (p<0.05). The gender, the fusion segment number, the pre-CACD, the pre-and-po CACD, the preoperative cervical spinal canal ratio, and the upper and lower disc height (DH) showed no statistical difference between the two groups (p>0.05). The results of logistic regression analysis showed that there were significant correlations in the following characteristics: age, postoperative po-CACD, and the PDD (p<0.05). Of all these characteristics, the correlation of age was the highest (R=1.820).

CONCLUSIONS: Age, po-CACD, and PDD were risk factors for ASD after ACDF. The older the operation age, the worse the recovery was of postoperative physiological curvature of cervical spine, and a PDD < 5 mm was more likely to lead to ASD.

Keywords: intervertebral disc degeneration, Spinal Fusion, Uterine Cervical Diseases

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750