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09 July 2017 : Clinical Research  

Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study

Huixian Han12ABCDEF, Han Deng12ABCDEF, Tao Han3ABCDEF, Haitao Zhao4ACD, Feifei Hou1B, Xingshun Qi1ACDEF*

DOI: 10.12659/MSM.902440

Med Sci Monit 2017; 23:3324-3334

Abstract

BACKGROUND: Whether the presence of type 2 diabetes mellitus (T2DM) increases the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) cirrhosis patients is controversial. We conducted a retrospective case-control study to evaluate this issue.

MATERIAL AND METHODS: We considered all patients diagnosed with HBV-related liver cirrhosis at our hospital from July 2011 to June 2014. The case (n=91) and control (n=91) groups were HBV cirrhosis patients with and without T2DM, respectively. They were matched at a ratio of 1: 1 according to the individual age (±2 years) and same sex and Child-Pugh score.

RESULTS: None of the baseline data were significantly different between the 2 groups. The percentage of HCC was similar between the 2 groups (case versus control group: 34.1% versus 46.2%, P=0.13). In the case group, sex (P=0.002), alkaline phosphatase (P<0.001), g-glutamine transferase (P=0.001), and sodium (P=0.003) were associated with the risk of HCC. In the control group, platelet (P=0.041), alanine aminotransferase (P=0.034), aspartate aminotransferase (P=0.026), alkaline phosphatase (P<0.001), and γ-glutamine transferase (P<0.001) were associated with the risk of HCC.

CONCLUSIONS: T2DM may not be a risk factor for the presence of HCC in HBV cirrhosis.

Keywords: Diabetes Mellitus, Hepatitis B virus, Liver Cirrhosis, Risk Factors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750