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29 May 2017 : Clinical Research  

Glycated Hemoglobin is Independently Associated with Albuminuria in Young Nondiabetic People with Obesity: A Cross-Sectional Study

Yanli Li1CE*, Juan Shi1C, Xiaolin Huang1C, Rui Wang1B, Bin Gu1B, Peiwen Liang1B, Shaoqian Zhao1B, Yingkai Sun1B, Wen Liu1C, Yuying Deng1B, Liuqing Xi1B, Dandan Zhao1B, Dalong Song1BG, Yanan Cao1E, Yifei Zhang1A, Weiqiong Gu1A, Jie Hong1AEFG

DOI: 10.12659/MSM.902450

Med Sci Monit 2017; 23:2612-2618

Abstract

BACKGROUND: The aim of this study was to explore the association between glycated hemoglobin (HbA1c) level and albuminuria in young nondiabetic people with obesity.

MATERIAL AND METHODS: A total of 537 young nondiabetic people with obesity were enrolled in this cross-sectional study, which was approved by the Rui-jin Hospital Ethics Committee. Albuminuria was defined as a urinary albumin-to-creatinine ratio (ACR) ≥30 mg/g. Multivariate logistic regression was used to analyze the association between HbA1c level and albuminuria.

RESULTS: Urinary ACR progressively increased across the tertiles of HbA1c level (P for trend <0.05). HbA1c levels were positively associated with the risk of albuminuria in the logistic regression analysis after adjustment for confounding factors. The adjusted odds ratio (OR) for albuminuria was 3.72 (95% confidence interval [CI], 1.25–11.00; P=0.017) when comparing between the highest (≥5.7%) and lowest tertiles of HbA1c level (≤5.3%). Moreover, an increment of 1 SD in HbA1c level increased the risk of albuminuria in a fully adjusted model (OR, 1.73; 95% CI, 1.25–2.46).

CONCLUSIONS: These data suggest that HbA1c level was independently associated with albuminuria in young nondiabetic people with obesity.

Keywords: Albuminuria, Hemoglobin A, Glycosylated, Obesity

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750