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24 May 2017 : Laboratory Research  

Fabrication and Characterization of Carbon Fiber-Reinforced Nano-Hydroxyapatite/Polyamide46 Biocomposite for Bone Substitute

Zhennan Deng1ABDEF, Hongjuan Han2ABCD, Jingyuan Yang1CEF, Yuanyuan Li1BC, Shengnan Du1BC, Jianfeng Ma1AFG*

DOI: 10.12659/MSM.903768

Med Sci Monit 2017; 23:2479-2487

Abstract

BACKGROUND: Ideal bone repair material should be of good biocompatibility and high bioactivity. Besides, their mechanical properties should be equivalent to those of natural bone. The objective of this study was to fabricate a novel biocomposite suitable for load-bearing bone defect repair.

MATERIAL AND METHODS: A novel biocomposite composed of carbon fiber, hydroxyapatite and polyamide46 (CF/HA/PA46) was fabricated, and its mechanical performances and preliminary cell responses were evaluated to explore its feasibility for load-bearing bone defect repair.

RESULTS: The resultant CF/HA/PA46 biocomposite showed a bending strength of 159–223 MPa, a tensile strength of 127–199 MPa and a tensile modulus of 7.7–10.8 GPa, when the CF content was 5–20% (mass fraction) in biocomposite. The MG63 cells, showing an osteogenic phenotype, were well adhered and spread on the surface of the CF/HA/PA46 biocomposite. Moreover, the cells vitality and differentiation on the CF/HA/PA46 biocomposite surface were obviously increased during the culture time and there was no significant difference between the CF/HA/PA46 biocomposite and HA/PA (as control) at all the experimental time (P>0.05).

CONCLUSIONS: The addition of CF into HA/PA46 composite manifest improved the mechanical performances and showed favorable effects on biocompatibility of MG63 cells. The obtained biocomposite has high potential for bone repair in load-bearing sites.

Keywords: Biocompatible Materials, Compomers, Materials Testing

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750