Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 February 2018 : Laboratory Research  

Baculoviral IAP Repeat Containing 6 (BIRC6) Is a Predictor of Prognosis in Prostate Cancer

Wenzhen Zhuang1ABC, Cuixia Zhang1CD, Furong Hao2DEF, Xicai Sun3FG

DOI: 10.12659/MSM.904052

Med Sci Monit 2018; 24: LBR839-845

Abstract

BACKGROUND: Baculoviral IAP repeat containing 6 (BIRC6), a member of the inhibitors of apoptosis protein (IAP) family, has been reported to be correlated with oncogenesis. The aim of this study was to investigate the prognostic significance of BIRC6 in prostate cancer, as well as its effects on prostate cancer cell lines.

MATERIAL AND METHODS: BIRC6 protein expression was investigated in 112 prostate cancer tissues and 86 benign prostate disease tissues using immunohistochemistry. Overall survival was assessed by Kaplan-Meier analysis with log-rank test. To evaluate the prognostic significance of BIRC6, Cox regression models were applied. The effects of BIRC6 on human prostate cancer cells were confirmed via small interfering RNA.

RESULTS: BIRC6 protein levels were significantly higher in prostate cancer tissues than that in benign prostate tissues (P<0.001). High BIRC6 expression was associated with advanced pathological stage (P=0.011) and positive metastasis (P=0.036). In addition, patients with high BIRC6 expression had worse survival than those with low expression (Log-rank test, P=0.002). Multivariate analysis demonstrated that BIRC6 expression was an independent prognostic factor for prostate cancer (HR=2.771, 95%CI=1.427–5.378, P=0.003). Furthermore, cell experiments suggested that BIRC6 knockdown inhibits cell proliferation and promote apoptosis (P<0.05 for all).

CONCLUSIONS: Upregulated BIRC6 predicts aggressive clinical characteristics and poor prognosis in prostate cancer patients. BIRC6 can regulate prostate cancer cell proliferation and apoptosis, which may be a potential therapeutic target.

Keywords: Betula, Prostatic Neoplasms

Add Comment 0 Comments

Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Clinical Research  

Procedure Dynamics in Transfemoral vs Transradial Cerebral Angiography: A Retrospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.947603  

Clinical Research  

Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemi...

Med Sci Monit In Press; DOI: 10.12659/MSM.946303  

Clinical Research  

Long-Term Outcomes of Implanon in Managing Adenomyosis: A 3-Year Prospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.945972  

Laboratory Research  

Linear Dimensional Accuracy in Maxillomandibular Records: A Comparative Study of Scannable and Transparent ...

Med Sci Monit In Press; DOI: 10.12659/MSM.947265  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,969,932

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,896

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,741

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   20,253

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750