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13 February 2018 : Clinical Research  

Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients

Xiao Bi1BCDEF*, Honglan Ai1C, Qiaoming Wu1B, Qiang Fan1B, Feng Ding1CD, Chun Hu1AD, Wei Ding1ADG

DOI: 10.12659/MSM.906269

Med Sci Monit 2018; 24: CLR897-902

Abstract

BACKGROUND: Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin-1β (IL-1β) is unclear in CKD patients.

MATERIAL AND METHODS: We conducted a cross-sectional study including 79 non-diabetic patients who received hemodialysis after the exclusion process. Homeostasis model assessment (HOMA-IR) and leptin adiponectin ratio (LAR) were used to evaluate IR. Inflammation was assessed through C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-1β evaluation. We tested associations of IR with IL-1β using logistic analysis and linear regression.

RESULTS: Patients were divided into a HOMA-IR-positive group and a HOMA-IR-negative group. Although there were no differences between the 2 groups in terms of etiological causes, age, sex, BMI, triglyceride, cholesterol, ferritin, uric acid, and inflammatory indicators such as CRP, we found that IL-6, TNF-α, and IL-1β were significantly increased in the HOMA-IR-positive group compared with the HOMA-IR-negative group. Moreover, IL-1β contributed to HOMA-IR positivity and was positively correlated with LAR after adjusting for possible confounding factors.

CONCLUSIONS: Insulin resistance correlates positively with IL-1β among non-diabetic hemodialysis patients, which suggests that IL-1β may be involved in the pathogenesis of IR in this setting.

Keywords: Insulin Resistance, Kidney Failure, Chronic

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750