22 March 2018 : Laboratory Research
Polymorphisms in Selected Genes and Their Association with Age-Related Macular Degeneration in a Chinese PopulationQing Huang1BCDE, Yi Xiang1AEFG*
Med Sci Monit 2018; 24: LBR1693-1700
BACKGROUND: Increasing evidence shows that polymorphisms in a number of genes can influence age-related macular degeneration (AMD) risk. This study aimed to investigate the association of CX3CR1 839C/T, CX3CR1 745G/A, PLEKHA1 958A/G, VEGFA +674C/T, and VEGFA +936C/T polymorphisms with AMD risk among Chinese.
MATERIAL AND METHODS: The polymorphisms were genotyped on 827 AMD patients and 827 controls, and the odds ratios (ORs) were calculated under allele, additive, recessive, and dominant genetic models. Logistic regression analysis was performed to control for potential confounders (age, sex, and smoking status).
RESULTS: We showed that all the 5 polymorphisms showed a significant association with AMD risk under the additive model (for homozygous mutant genotype) and at least 1 other genetic model, both before and after adjustment for the potential confounders. PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450–0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736–0.992, P=0.014), while all other polymorphisms were associated with an increased AMD risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141–6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231–6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227–5.993, P=0.011; VEGFA +674C/T, additive model: aOR=1.601, 95% CI=1.253–2.179, P<0.001, dominant model: aOR=1.287, 95% CI=1.058–1.570, P<0.001, allele model: OR=1.220, 95% CI=1.118–1.427, P<0.001; VEGFA +936C/T, additive model: aOR=1.509, 95% CI=1.105–2.311, P<0.001, recessive model: aOR=1.432, 95% CI=1.027–2.192, P=0.009, dominant model: aOR=1.207, 95% CI=1.031–1.514, P0.001, allele model: aOR=1.216, 95% CI=1.062–1.408, P<0.001).
CONCLUSIONS: We conclude that the 5 polymorphisms could serve as biomarkers for AMD susceptibility.
Keywords: Genetic Predisposition to Disease, Genotyping Techniques, Macular Degeneration, Odds Ratio, Polymorphism, Genetic
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic
Med Sci Monit 2022; 28:e939088
29 November 2022 : Clinical ResearchRetrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...
Med Sci Monit In Press; DOI: 10.12659/MSM.938647
24 November 2022 : Clinical ResearchA Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...
Med Sci Monit In Press; DOI: 10.12659/MSM.938665
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Funga...
Med Sci Monit 2022; 28:e939088
05 Dec 2022 : Database AnalysisImpact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Pe...
Med Sci Monit In Press; DOI: 10.12659/MSM.937737
02 Dec 2022 : Clinical ResearchValue of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...
Med Sci Monit In Press; DOI: 10.12659/MSM.938637
30 Nov 2022 : Clinical ResearchRetrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality in 170 Pati...
Med Sci Monit In Press; DOI: 10.12659/MSM.938674
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996