02 April 2018 : Laboratory Research
Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients
Chengzhong Zhang1BCE, Jie Huang1F, Yue Chen1D, Weimin Shi1AG*DOI: 10.12659/MSM.906507
Med Sci Monit 2018; 24: LBR1930-1935
Abstract
BACKGROUND: The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients.
MATERIAL AND METHODS: Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049220, and DNMT1 in peripheral blood mononuclear cells (PBMCs) from 18 diagnosed SLE patients and 10 healthy controls.
RESULTS: We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients. The expression level of DNMT1 is positively correlated with the expressions of hsa_circ_0049224 and has_circ_0049220. Moreover, there was a negative correlation between the SLE Disease Activity Index (SLEDAI) and the expressions of hsa_circ_0049224 and has_circ_0049220. We also found that these 2 circRNAs are associated with some clinical characteristics of SLE.
CONCLUSIONS: Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE.
Keywords: Biological Markers, Systemic Lupus Erythematous, clinical
Editorial
01 October 2024 : Editorial
Editorial: Potentials and Pitfalls in Targeting Glucagon-Like Peptide-1 (GLP-1) in the Management of Increasing Levels of ObesityDOI: 10.12659/MSM.946675
Med Sci Monit 2024; 30:e946675
In Press
Clinical Research
Cold Pressor Test Induces Significant Changes in Internal Jugular Vein Flow Dynamics in Healthy Young AdultsMed Sci Monit In Press; DOI: 10.12659/MSM.946055
Clinical Research
Serum Albumin-to-Creatinine Ratio Predicts One-Year Mortality in Elderly Patients with Non-ST-Elevation Acu...Med Sci Monit In Press; DOI: 10.12659/MSM.945516
Clinical Research
Uric Acid to Albumin Ratio as a Predictive Marker for Intracoronary Thrombus Severity in ST-Segment Elevati...Med Sci Monit In Press; DOI: 10.12659/MSM.945832
Database Analysis
Systematic Review of Arthroscopic Bankart Repair Outcomes for Anterior Shoulder InstabilityMed Sci Monit In Press; DOI: 10.12659/MSM.945942
Most Viewed Current Articles
17 Jan 2024 : Review article 6,057,955
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,853,190
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 694,082
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 258,356
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074