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01 June 2018 : Clinical Research  

Endoscopic Ultrasound Imaging for Differential Diagnosis of Pancreatic Neoplasms: A 7-Year Study in a Chinese Population

Binxin Cui1BCDEF, Weili Fang1B, Samiullah Khan1D, Shu Li1B, Yixiang Chang1B, Bangmao Wang1B, Wentian Liu1A*

DOI: 10.12659/MSM.907516

Med Sci Monit 2018; 24: DIA3653-3660

Abstract

BACKGROUND: Currently, non-invasive methods for screening pancreatic cancer are lacking. There is little information regarding whether endoscopic ultrasound (EUS) imaging has a discriminatory ability for detecting benign and malignant pancreatic neoplasms. In this study, we retrospectively analyzed the demographic, clinicopathologic, and EUS features and follow-up information.

MATERIAL AND METHODS: A total of 58 patients with pancreatic neoplasms who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) over a 7-year period (2009–2016) at our Department of Digestive Diseases were enrolled in our study.

RESULTS: Of the 58 patients, 38 (65.5%) were diagnosed with malignant pancreatic neoplasms and 20 (34.5%) were benign ones. Of all the EUS findings, size of neoplasm (P=0.037) and regularity of margin (P=0.011) were significantly different between malignant and benign pancreatic neoplasms. However, age, sex, location, echo pattern, and dilation of main pancreatic duct did not show any significant difference (P>0.05). Size combined with regularity to detect malignant pancreatic neoplasms showed the following diagnostic values: sensitivity, 73.68%; specificity, 90%; positive predictive value, 76.60%; negative predictive value 81.82%; and area under the receiver operating characteristic curve, 0.887 (95% CI: 0.777–0.955, P<0.0001).

CONCLUSIONS: Our results showed the high value of EUS for differentiating malignant pancreatic neoplasms from benign ones. Due to this and its non-invasive nature, EUS should be the first-line method for detection of neoplastic pancreatic lesions.

Keywords: Diagnosis, Endoscopy, Gastrointestinal

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750