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15 June 2018 : Review article  

Liver Disease During Pregnancy: A Challenging Clinical Issue

Ivana Mikolasevic1ABCDEFG*, Tajana Filipec-Kanizaj2ABDE, Ivan Jakopcic1ABDE, Iva Majurec3ABDE, Alemka Brncic-Fischer4ABDE, Nikola Sobocan2ABDE, Irena Hrstic5ABEF, Tea Stimac4ABDE, Davor Stimac1ABD, Sandra Milic1ABDEG

DOI: 10.12659/MSM.907723

Med Sci Monit 2018; 24: REV4080-4090

Abstract

One of the least studied topics in the field of obstetrics is liver disease during pregnancy, which creates a challenge for both gynecologists and hepatologists. Approximately 3% of pregnant women are affected by some form of liver disease during pregnancy. Some of these conditions can be fatal for both the mother and child. In addition, 3 types of liver disease need to be differentiated during pregnancy. One type is liver disease directly related to pregnancy, which can occur at a specific time during pregnancy. Another type is liver disease not related to pregnancy, which can occur at any time, such as viral- or drug-induced hepatitis. Furthermore, pregnancy can occur in women with pre-existing liver disease. It is essential that the clinicians are familiar with this disorder so they can respond promptly and appropriately in all of these situations, especially when emergency delivery is needed and must not be postponed.

Keywords: Delivery, Obstetric, Liver Diseases, Pregnancy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750