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21 January 2018 : Laboratory Research  

Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)

Rong Wang1BCE, Laixiu Yang2BE, Shen Li3BC, Dongmei Ye4BD, Lihong Yang4BD, Qingyan Liu5BC, Zibo Zhao4BD, Qing Cai6BD, Junzhen Tan6ADE*, Xiuli Li7AD

DOI: 10.12659/MSM.908022

Med Sci Monit 2018; 24: LBR412-420

Abstract

BACKGROUND: Quercetin, nature’s most common flavonoid, possesses anticarcinogenic properties against various forms of cancer. The aim of this study was to investigate the effect of quercetin on breast cancer stem cells in the MDA-MB-231 cell line, and to elucidate the possible mechanisms for those effects.

MATERIAL AND METHODS: We evaluated breast cancer stem cell proliferation, clone generation, and mammosphere formation to determine the effect of quercetin treatment on breast cancer stem cells.

RESULTS: In our study, quercetin suppressed breast cancer stem cell proliferation, self-renewal, and invasiveness. It also lowered the expression levels of proteins related to tumorigenesis and cancer progression, such as aldehyde dehydrogenase 1A1, C-X-C chemokine receptor type 4, mucin 1, and epithelial cell adhesion molecules.

CONCLUSIONS: These results indicate that quercetin targets and destroys breast cancer stem cells, making it a potential novel drug in the fight against cancer.

Keywords: Neoplastic Stem Cells, Quercetin, Triple Negative Breast Neoplasms

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750