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03 October 2018 : Laboratory Research  

Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma

Yong Tong1ABCDEFG, Yinzhou Xiang2CDE, Bao Li3ABCDEFG, Shijie Bao1ABCDEFG, Ying Zhou1ABCDEFG, Wen Yuan1DEF, Yu Ling1ABCDEF, Dan Hao1ABDEFG, Huamin Zhu1ABCDEF, Zhiqiang Sun4ABCD*

DOI: 10.12659/MSM.908813

Med Sci Monit 2018; 24: LBR7015-7022


BACKGROUND: The objective of this study was to detect the association between ERCC excision repair 2, TFIIH core complex helicase subunit (ERCC2) gene polymorphisms and diffuse large B-cell lymphoma (DLBCL) susceptibility.

MATERIAL AND METHODS: This study used a case-control design. ERCC2 gene rs1799793 (Asp312Asn) and rs13181 (Lys751Gln) polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) both in DLBCL patients and healthy controls. The association between ERCC2 gene polymorphisms and DLBCL risk was assessed by χ² test. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were used to address the association strength. Subgroup analyses were also performed to investigate the genetic effects of ERCC2 polymorphisms on clinical characteristics of DLBCL patients.

RESULTS: A significant association was discovered between the rs1799793 A allele and increased DLBCL risk (P=0.031, OR=1.928, 95% CI=1.052–3.534). The C allele of rs13181 was obviously associated with elevated DLBCL susceptibility (P=0.047, OR=1.820, 95% CI=1.002–3.305). The subgroup analysis demonstrated that rs1799793 and rs13181 polymorphisms had no relationship with serum lactate dehydrogenase level, nidus number, B-symptoms, Ann Arbor stages, or immunological types in DLBCL cases (P>0.05 for all).

CONCLUSIONS: Minor allele carriers of ERCC2 gene rs1799793 (Asp312Asn) and rs13181 (Lys751Gln) polymorphisms had higher susceptibility to DLBCL.

Keywords: Lymphoma, Large B-Cell, Diffuse, Polymorphism, Genetic, Xeroderma Pigmentosum Group D Protein

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750