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22 June 2018 : Clinical Research  

Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues

Mert Ulaş Barut1ABCDEFG*, Murat Bozkurt2ACDEF, Mehmet Kahraman3B, Engin Yıldırım4B, Necat Imirzalioğlu5ACE, Ayhan Kubar5ACDE, Sibel Sak1CDF, Elif Ağaçayak6ACEF, Tarık Aksu5AE, Hakan Çoksüer7AE

DOI: 10.12659/MSM.908832

Med Sci Monit 2018; 24: CLR4288-4294


BACKGROUND: Thrombophilic gene polymorphism is known to be a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic genes polymorphism in RPL risk. This study was conducted to understand the relationship of the mutations of some thrombophilia-associated gene polymorphism (heterozygous/homozygous) with RPL. We compared patients with 2 abortions to patients with 3 or more abortions among Turkish women.

MATERIAL AND METHODS: In this study, patients previously diagnosed with habitual abortus at Obstetrics and Gynecology outpatient clinics in Turkey between 2012 and 2016 were included. In their peripheral blood, we detected factor V Leiden H1299R, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, and PAI-1 4G/4G gene mutations.

RESULTS: In this study, we have observed statistically meaningful data (P<0.01) related to the relationship between RPL and thrombophilia-associated gene polymorphisms such as heterozygous factor V Leiden H1299R, heterozygous prothrombin G20210A, PAI-1 4G/5G, and PAI-1 4G/4G.

CONCLUSIONS: We found that diagnosis of thrombophilic genes polymorphism is useful to determine the causes of RPL, recognizing that this multifactorial disease can also be influenced by various acquired factors, including reproduction-associated risk factors and prolonged immobilization.

Keywords: Abortion, Habitual, Polymorphism, Genetic, Thrombophilia



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Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939088

Med Sci Monit 2022; 28:e939088


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750