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22 August 2018 : Animal Research  

Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats

Emine Kilic-Toprak1ABCDEFG, Ozgen Kilic-Erkek1BDEFG, Gulcin Abban-Mete2BDEFG, Vildan Caner3BDEFG, Ikbal Cansu Baris4BEFG, Gurkan Turhan2BEFG, Vural Kucukatay1BDEFG, Hande Senol5CEFG, Oktay Kuru6BDEFG, Melek Bor-Kucukatay1ABCDEFG*

DOI: 10.12659/MSM.908992

Med Sci Monit 2018; 24: ANS5851-5859

Abstract

BACKGROUND: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process.

MATERIAL AND METHODS: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry.

RESULTS: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR.

CONCLUSIONS: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR- and BP-lowering effect of exercise. Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk.

Keywords: Aorta, Heme Oxygenase (Decyclizing), Rats, Inbred SHR, Swimming

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750