07 April 2018 : Special report
Microbiome and Health: Ramifications of Intelligent Deception
George B. Stefano12AEF*, Rachel Fine3AEF, Richard M. Kream4AEFDOI: 10.12659/MSM.910248
Med Sci Monit 2018; 24: EDT2060-2062
Abstract
Ten thousand years ago, the foundation for agricultural development and animal domestication was laid. Neolithic founder crops were carbohydrate-laden cereal grasses that facilitated transformation of hunter-gather societies into ancient civilizations with realistic capabilities for population expansion. In the last 3–4 decades, however, debilitating medical consequences of a progressively narrowed high caloric diet incorporating processed carbohydrates, animal protein, saturated fat and cholesterol, are translated into a global epidemic of obesity linked to metabolic and endocrine disorders, which, in part, emerged from the enhancement of our longevity. The initiation and progression of pathophysiological processes associated with this restrictive diet may well reside in the gastrointestinal tract. The critical role of human gut microbiome in facilitating normal gut physiology and linkages to other physiological systems points to its significance in comorbid pathologies when its diversity is compromised. Cortical desensitization to the potentially damaging effects of intentionally restricted high carbohydrate diets is progressively enhanced by compromised metabolic activities and widespread pro-inflammatory processes within all organ systems. Our cognitive ability must overcome the desire for comfort foods. The solution is simple: minimize “processed” foods and those of similar commercial origin in our diet, restoring a more diverse gut microbiome. Initially the solution may be costly, however, within the scope of sustained healthy longevity it will “payoff”.
Keywords: Diabetes Mellitus, Type 2, Carbohydrates, Obesity, Symbiosis, DNA, genetic therapy, Hypoglycemic Agents, Cognition, Mitochondria
Editorial
01 September 2024 : Editorial
Editorial: Reasons for Increasing Global Concerns for the Spread of MpoxDOI: 10.12659/MSM.946343
Med Sci Monit 2024; 30:e946343
In Press
Clinical Research
Efficacy of Lung Ultrasound vs Chest X-Ray in Detecting Lung Consolidation and Edema in Premature Infants i...Med Sci Monit In Press; DOI: 10.12659/MSM.944426
Laboratory Research
Three-Dimensional Optical Study on the Effects of Microwave Glazing on Surface Roughness of Zirconia-Reinfo...Med Sci Monit In Press; DOI: 10.12659/MSM.945130
Clinical Research
Prognostic Significance of the Advanced Lung Cancer Inflammation Index in Metastatic Small Cell Lung Cancer...Med Sci Monit In Press; DOI: 10.12659/MSM.945752
Review article
Dangerous Intersection of Alcoholism and Othello Syndrome: A Comprehensive Review of Delusional Jealousy an...Med Sci Monit In Press; DOI: 10.12659/MSM.945616
Most Viewed Current Articles
17 Jan 2024 : Review article 6,036,132
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,828,794
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 692,732
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 257,192
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074