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16 September 2018 : Clinical Research  

Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics

Xiuli Yi1ABCDEF, Tingting Cui1BCDEF, Shuli Li1BCDF, Yuqi Yang1BCDF, Jiaxi Chen1BCD, Sen Guo1BCD, Zhe Jian1AEF, Chunying Li1AFG, Tianwen Gao1AFG, Ling Liu1ACDF, Kai Li1AFG*

DOI: 10.12659/MSM.910515

Med Sci Monit 2018; 24: CLR6489-6497

Abstract

BACKGROUND: Multiple studies have implicated a role for CD8+T cell-mediated immune response to autoantigens in vitiligo. However, the antigen-specific T lymphocyte reactivity against the peptide epitopes is diverse among different world populations. This study aimed to identify the risk HLA-A allele in vitiligo and study CD8+ T cell reactivity to 5 autoantigenic peptides in Han Chinese populations, and to analyze the association of CD8+ T cell reactivity with disease characteristics.

MATERIAL AND METHODS: The risk HLA-A allele was analyzed by case-control study. Enzyme linked immunospot (ELISPOT) assay was used to compare T cell reactivity to the 5 autoantigenic peptides between vitiligo patients and healthy controls, then we analyzed the association of CD8+ T cell reactivity to 2 positive peptides with disease activity and area of skin lesions.

RESULTS: The results indicated that the most frequent allele in the Han Chinese vitiligo patients was the HLA-A*02: 01 allele with a significantly higher frequency compared to controls (20.20% versus 13.79%, P=6.64×10–5). The most frequently encountered epitopes were 2 gp100 modified peptides, IMDQVPFSV and YLEPGPVTV, whereas a weak T cell reactivity against tyrosinase and Melan-A/MART-1 were evaluated. Moreover, we demonstrated that T cell reactivity against the 2 positive peptides was significantly associated with disease characteristics including disease activity and area of skin lesions.

CONCLUSIONS: Our findings showed that the HLA-A*02: 01 allele was the major risk HLA-A allele, and 2 gp100 modified peptides were identified as autoantigens and were found to be closely related to disease characteristics which might play a critical role in Han Chinese vitiligo patients.

Keywords: Autoantigens, CD8-Positive T-Lymphocytes, HLA-A Antigens, Vitiligo

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750