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04 June 2018 : Laboratory Research  

Prognostic Value of Dynactin mRNA Expression in Cutaneous Melanoma

Qiaoqi Wang1BCDEF, Xiangkun Wang2DF, Qian Liang1F, Shijun Wang3DE, Xiwen Liao2DEF, Dong Li1A*, Fuqiang Pan1G

DOI: 10.12659/MSM.910566

Med Sci Monit 2018; 24: LBR3752-3763

Abstract

BACKGROUND: Dynactin (DCTN) is a multi-subunit protein encoded by DCTN genes for 6 subunits. In different diseases the DCTN genes may have different roles; therefore, we investigated the prognostic potential of DCTN mRNA expression in cutaneous melanoma (CM).

MATERIAL AND METHODS: Data for DCTN mRNA expression in CM patients were obtained from the OncoLnc database, which contains updated gene expression data for 459 CM patients based on the Cancer Genome Atlas. Kaplan-Meier analysis and a Cox regression model were used to determine overall survival (OS) with calculation of hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS: The multivariate survival analysis showed that individually low expression of DCTN1, DCTN2, and DCTN5 and high expression of DCTN6 were associated with favorable OS (adjusted P=0.008, HR=0.676, 95% CI=0.506–0.903; adjusted P=0.004, HR=0.648, 95% CI=0.485–0.867; adjusted P=0.011, HR=0.686, 95% CI=0.514–0.916; and adjusted P=0.018, HR=0.706, 95% CI=0.530–0.942, respectively). In a joint-effects analysis, combinations of low expression of DCTN1, DCTN2, and DCTN5 and high expression of DCTN6 were found to be more highly correlated with favorable OS (all P<0.05).

CONCLUSIONS: Our findings suggest that downregulated DCTN1, DCTN2, and DCTN5 and upregulated DCTN6 mRNA expression in CM are associated with favorable prognosis and may represent potential prognostic biomarkers. Moreover, use of the 4 genes in combination can improve the sensitivity for predicting OS in CM patients.

Keywords: Dynactin, Prognosis

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Editorial

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750