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16 April 2019 : Clinical Research  

Study on the Significance of Folate Receptor-Mediated Staining Solution (FRD) Staining in Screening High Grade Cervical Lesions

Songshu Xiao1ABF, Hui Xie1F, Xiaogang Zhu1C, Xiang Li1F, Shuijing Yi1BD, Xingliang Deng1BD, Min Xue1AF*

DOI: 10.12659/MSM.911402

Med Sci Monit 2019; 25:2792-2801


BACKGROUND: The aim of this study was to investigate the significance of folate receptor-mediated staining solution (FRD) in examination of cervical lesions during gynecological examination.

MATERIAL AND METHODS: A total of 404 patients participated in this study. FRD staining was applied to screen high grade cervical lesions. ThinPrep cytology test (TCT) and human papillomavirus (HPV) testing were also used for screening high grade cervical lesions. Coincidence rate and KAPPA value of different methods were compared by SPSS software.

RESULTS: As for CIN2+ and CIN3+, sensitivities for HPV testing were (96.92% and 97.78%) >TCT classification 1 (90.77% and 91.11%) >FRD staining (80.00% and 86.67%) >TCT classification 2 (70.77% and 77.78%), respectively. While specificities for HPV testing were (7.08% and 6.44%)

CONCLUSIONS: FRD staining was capable of detecting cervical lesions rapidly and is a cost-effective method for routine cervical lesions screening.

Keywords: 3T3 Cells, DNA Probes, HPV, I-kappa B Proteins, Silver Staining, Aged, Cervical Intraepithelial Neoplasia, Cervix Uteri, Early Detection of Cancer, Folate Receptors, GPI-Anchored, Folic Acid, Mass Screening, Middle Aged, Papillomaviridae, Papillomavirus Infections, Sensitivity and Specificity, Staining and Labeling, Uterine Cervical Neoplasms, Vaginal Smears

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Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750