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06 December 2018 : Clinical Research  

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O⁶-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas

Xiao-chun Wang1ADEFG, Ying Lei1ADEF, Le Wang1BC, Yan Tan1BC, Jiang-bo Qin1BC, Guo-lin Ma2ADFG*, Hui Zhang1AEFG

DOI: 10.12659/MSM.911631

Med Sci Monit 2018; 24: CLR8822-8830


BACKGROUND: Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas.

MATERIAL AND METHODS: Sixty-six patients with pathologically proven astrocytomas were enrolled in this study. All patients underwent conventional MRI head scanning, DKI scanning, and enhanced scanning under the same conditions. Spearman’s rank correlation analysis and Bonferroni correction were used to compare the values of DKI and the expression levels of GFAP, Topo IIα, and MGMT between the 2 groups.

RESULTS: Mean kurtosis (MK) values were negatively correlated with the expression of GFAP (r=–0.836; P=0.03). However, these were positively correlated with the expression of Topo IIα (r=0.896; P=0.01). Moreover, fractional anisotropy (FA) values were not correlated with the expression of GFAP (r=0.366; P=0.05), Topo IIα (r=–0.562; P=0.05), or MGMT (r=–0.153; P=0.10).

CONCLUSIONS: MK was significantly associated with the expression of GFAP and Topo IIα. To a certain extent, applying DKI may show the biological behavior of tumor cell differentiation, proliferation activity, invasion, and metastasis, and guide individual treatment.

Keywords: Astrocytoma, Diffusion Magnetic Resonance Imaging, DNA Topoisomerases, Type II, Glial Fibrillary Acidic Protein, O(6)-Methylguanine-DNA Methyltransferase



01 October 2022 : Editorial  

Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.938532

Med Sci Monit 2022; 28:e938532


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750