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26 November 2018 : Clinical Research  

Effect of Age on Prognosis of Gastric Signet-Ring Cell Carcinoma: A SEER Database Analysis

Jun Ren1E, Gengming Niu1B, Xin Wang1D, Tao Song1C, Zhiqing Hu1F, Chongwei Ke1A*

DOI: 10.12659/MSM.911766

Med Sci Monit 2018; 24: CLR8524-8532

Abstract

BACKGROUND: Age is a prognostic factor for multiple malignancies. In this study, we aimed to assess the effect of age on the cancer-specific survival (CSS) of patients with gastric signet-ring cell carcinoma (SRC).

MATERIAL AND METHODS: Information on patients with gastric SRC was extracted from the Surveillance, Epidemiology, and End Results database. Chi-squared tests were used to demonstrate distribution differences, and Kaplan-Meier analysis and Cox regression models were used to analyze the impact of age on CSS.

RESULTS: A total of 4596 patients were enrolled and divided into 3 subgroups according to age (<45, 45–74, and >74 years old). Higher percentages of T4, N2, and M1 disease were observed in the <45-year-old group (all P<0.001). Kaplan-Meier plots showed that the youngest group had the most favorable 5-year CSS rate (36.3%), which remained true after stratification according to tumor stage. Multivariate Cox regression models demonstrated a poorer survival outcome for >74-year-old than for <45-year-old patients (hazard ratio 1.841, 95% confidence interval 1.636–2.071; P<0.001).

CONCLUSIONS: Young age is associated with improved survival, even though younger patients generally present with a more advanced-stage disease.

Keywords: Carcinoma, Signet Ring Cell, SEER Program

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750