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21 January 2019 : Clinical Research  

Effect of Interventional Therapy on IL-1β, IL-6, and Neutrophil-Lymphocyte Ratio (NLR) Levels and Outcomes in Patients with Ischemic Cerebrovascular Disease

Yongnan Hao1AE, Ziyou Qi1BC, Ying Ding2BC, Xiangli Yu1BC, Li Pang3AE*, Teng Zhao4CE

DOI: 10.12659/MSM.912064

Med Sci Monit 2019; 25:610-617

Abstract

BACKGROUND: This study investigated the clinical effect of interventional therapy in ischemic cerebrovascular disease (ICD).

MATERIAL AND METHODS: A retrospective analysis was performed on 260 ICD patients who were divided into a control group (122 patients, conventional drug treatment) and an observation group (138 patients, interventional therapy plus conventional drug treatment). Enzyme-linked immunosorbent assay was used to examine the expression of IL-1β, IL-6, and NLR. Furthermore, neurological deficit scores and Barthel index scores as well as the correlation of IL-1β, IL-6 and NLR were examined in these 2 groups.

RESULTS: The expression of IL-1β, IL-6, and NLR significantly decreased in both groups after 1 week or 4 weeks of treatment compared with before treatment (P<0.05). Significant differences in neurological impairment scores were detected between these 2 groups after 4 weeks of treatment (P<0.05), and the control group showed higher neurological deficit scores than did the observation group (P<0.05). Barthel index scores were significantly higher after treatment than before treatment in the control and observation group (P<0.05), and the control group had lower Barthel index scores than did the observation group (P<0.05). Pearson correlation analysis showed that IL-1β, IL-6, and NLR expression were positively correlated in ICD patients (P<0.05).

CONCLUSIONS: Interventional surgery combined with conventional drug therapy can reduce serum IL-1β and IL-6 levels, decrease neurological impairment, and improve the quality of life of patients. The combined treatment group showed better outcomes than did the group that received the drug alone; therefore, combined therapy is suitable for promoting better clinical outcomes.

Keywords: Cerebrovascular Disorders, Hypoxia-Ischemia, Brain, Nervous System Diseases, Adult, Aged, Brain Ischemia, China, Enzyme-Linked Immunosorbent Assay, Interleukin-6, Interleukin-8, Lymphocytes, Middle Aged, Neutrophils, Quality of Life, Retrospective Studies, Treatment Outcome

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750