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08 April 2019 : Clinical Research  

Correlations of Changes in Brain Natriuretic Peptide (BNP) and Cardiac Troponin I (cTnI) with Levels of C-Reactive Protein (CRP) and TNF-α in Pediatric Patients with Sepsis

Yue Zhang1A*, Ya Luo1BC, Gulibaihairenmu Nijiatijiang1CD, Kaiyishaer Balati1DE, Yaxiaer Tuerdi1EF, Lin Liu1FG

DOI: 10.12659/MSM.912318

Med Sci Monit 2019; 25:2561-2566


BACKGROUND: This study investigated the changes in plasma brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) levels in pediatric patients with sepsis, and explored their relationships with serum inflammatory factors in pediatric patients.

MATERIAL AND METHODS: A total of 120 pediatric patients with sepsis admitted to and treated at our hospital from 2013 to 2017 were divided into 4 groups: a systemic inflammatory response syndrome (SIRS) group (n=28), a sepsis group (n=35), a severe sepsis group (n=27), and a septic shock group (n=30). Plasma BNP, cTnI, and creatine kinase-MB (CK-MB) levels in pediatric patients in the 4 groups were measured, and the correlations of BNP and cTnI with plasma inflammatory factors C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) were investigated.

RESULTS: The plasma BNP and cTnI levels in pediatric patients with sepsis were significantly higher than those in the SIRS group (p<0.05). After hospitalization and treatment, levels of BNP and cTnI in pediatric patients were decreased. The concentrations of BNP and cTnI were correlated with CRP level (r=0.88 and 0.88, respectively). The associations (r value) of BNP and cTnI with TNF-α levels were 0.35 and 0.48, respectively.

CONCLUSIONS: The levels of plasma BNP and cTnI are associated with the severity of sepsis in pediatric patients, and were positively correlated with CRP and TNF-α levels, which provides a novel strategy for the early diagnosis and evaluation of sepsis in pediatric patients.

Keywords: Natriuretic Peptide, Brain, Sepsis, Systemic Inflammatory Response Syndrome, C-Reactive Protein, Child, Child, Preschool, Creatine Kinase, MB Form, Shock, Septic, troponin I

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750