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10 January 2019 : Clinical Research  

Prognostic Value of Quantitative Perfusion Parameters by Enhanced Ultrasound in Endometrial Cancer

Maoshan Zhang1B, Yun Qiu2BCE, Lei Zhao2DFG, Xu Zhang3DE, Jing Wang4EG, Chen Zhang3BCD, Cuijing Chen5A*, Fengqin Shen2AB

DOI: 10.12659/MSM.912782

Med Sci Monit 2019; 25:298-304


BACKGROUND: Tumor perfusion is significantly associated with the development and aggressiveness of endometrial cancer. The aim of this study was to assess the prognostic value of quantitative perfusion parameters measured by contrast-enhanced ultrasonography (CEUS) in endometrial cancer before surgery.

MATERIAL AND METHODS: A total of 223 patients with endometrial cancer were included between 1 May 1 2013 and 1 May 1 2017 for preoperative CEUS. The mean enhancement rate (ER) was calculated as enhancement intensity (EI)/rise time (RT) results from time‑intensity curve (TIC) during CEUS. After a mean follow-up of 33.5±9.9 months, the correlation of ER and postoperative overall survival (OS) and disease-free survival (DFS) was analyzed using univariate and multivariate analysis.

RESULTS: The optimal cutoff ER value predicting survival based on the ROC curve was 1.8 dB/s. Kaplan-Meier univariate analysis demonstrated that a patient with a high ER level had worse DFS and OS than those with a low ER (DFS, P<0.01; OS, P<0.05). In multivariate analysis, ER was confirmed as an independent predictor for both recurrence (HR, 1.68; 95% CI: 1.01–7.73) and OS (HR, 1.98; 95%CI: 1.01–7.83) for patients with endometrial cancer (both P<0.05).

CONCLUSIONS: Perfusion variables measured by CEUS are significantly useful predictive factor for postoperative survival in endometrial cancer.

Keywords: Endometrial Neoplasms, Hemoperfusion, Prognosis, Ultrasonography, Aged, Disease-Free Survival, Kaplan-Meier Estimate, Middle Aged, perfusion imaging, Retrospective Studies, Survival, Survival Rate

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01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750