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31 January 2019 : Review article  

Correlation Between Smoking and Passive Smoking with Multiple Sclerosis and the Underlying Molecular Mechanisms

Zhaowei Wang1BE, Jianpin Xie1AC, Chenglong Wu1FG*, Guirong Xiao1D

DOI: 10.12659/MSM.912863

Med Sci Monit 2019; 25:893-902

Abstract

Multiple sclerosis (MS) is a chronic immune-mediated disease of the spinal cord and brain. Many studies have shown that smoking and passive smoking are key environmental risk factors for MS. Here, we provide an overview of the human leukocyte antigen (HLA) gene studies on smoking and MS risk, and we discuss recent studies on between epigenetics and smoking-induced MS. In addition, in this review we also summarize current research advances in biological pathways and smoking-induced MS. This review provides an overview of studies on the association between smoking, passive smoking, and MS susceptibility, and the underlying molecular mechanism.

Keywords: DNA Methylation, HLA Antigens, Multiple Sclerosis, Smoking, Tobacco Smoke Pollution, cigarette smoking, Epigenesis, Genetic, Genetic Predisposition to Disease, Risk Factors

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Editorial

01 March 2024 : Editorial  

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Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750