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26 February 2019 : Clinical Research  

Correlations of C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Insulin Resistance with Cerebral Infarction in Hypertensive Patients

Jiang Zhang1BE, Yunxia Wu1CF, Zhiqiang Gao1ADG*

DOI: 10.12659/MSM.912898

Med Sci Monit 2019; 25:1506-1511

Abstract

BACKGROUND: The aim of this study was to investigate the correlations of C-reactive protein (CRP), interleukin-6 (IL-6), and insulin resistance (IR) with cerebral infarction in hypertensive patients.

MATERIAL AND METHODS: A total of 80 patients with cerebral infarction admitted to our hospital from March 2016 to November 2017 were selected and divided into 2 groups according to the diameter of cerebral infarction, namely, lacunar cerebral infarction group (n=40) and cerebral infarction group (n=40). The levels of high-sensitivity CRP (hs-CRP) and IL-6, homeostasis model assessment of IR (HOMA-IR) index and blood pressure level were compared between the 2 groups. The correlations of hs-CRP level, IL-6 level, and IR with the diameter of cerebral infarction, as well as the relationships of hs-CRP level and IR with the neurological function score after cerebral infarction were analyzed.

RESULTS: The levels of hs-CRP and IL-6 in the cerebral infarction group were significantly higher than those in the lacunar cerebral infarction group (P<0.05). The cerebral infarction group had a markedly higher HOMA-IR index than the lacunar cerebral infarction group (P<0.05), but it had remarkably decreased systolic blood pressure and diastolic blood pressure compared with those in the lacunar cerebral infarction group (P<0.05). There were positive correlations of hs-CRP level, IL-6 level, and IR with the diameter of cerebral infarction (P<0.05). The hs-CRP level and IR had positive correlations with the neurological function score after cerebral infarction (P<0.05).

CONCLUSIONS: In hypertensive patients complicated with cerebral infarction, the body’s inflammatory factors, and IR are positively correlated with the diameter of cerebral infarction, as well as the neurological prognosis of the patients.

Keywords: Interleukin-6, Metabolic Syndrome X, white coat hypertension, Aged, 80 and over, Blood Glucose, Blood Pressure, C-Reactive Protein, cerebral infarction, Hypertension, Insulin Resistance, Stroke, Lacunar

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750