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23 January 2019 : Clinical Research  

Neuron-Specific Enolase Is an Independent Prognostic Factor in Resected Lung Adenocarcinoma Patients with Anaplastic Lymphoma Kinase Gene Rearrangements

Shouying Li123E, Lianjing Cao123D, Xinyue Wang123C, Fan Wang123B, Liuchun Wang123F, Richeng Jiang123A*

DOI: 10.12659/MSM.913054

Med Sci Monit 2019; 25:675-690

Abstract

BACKGROUND: An extensive body of research reveals the clinical value of serum tumor markers in lung cancer patients, including carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), cytokeratin-19 fragments (Cyfra21-1), and neuron-specific enolase (NSE), but little is known about the clinical properties of these serum tumor markers in anaplastic lymphoma kinase (ALK)-positive lung cancer patients.

MATERIAL AND METHODS: We retrospectively analyzed 54 patients harboring ALK rearrangements and 520 patients without ALK rearrangements, and all these patients were treated exclusively by surgery between 2011 and 2016.

RESULTS: NSE level (P=0.007 for OS) was identified as an independent prognostic factor among patients with resected ALK-positive adenocarcinoma of the lung.

CONCLUSIONS: A high level of NSE is associated with worse outcome among resected lung adenocarcinoma patients harboring ALK rearrangements.

Keywords: Adenocarcinoma, Carcinoembryonic Antigen, Phosphopyruvate Hydratase, Adenocarcinoma of Lung, Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Antigens, Neoplasm, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, China, Keratin-19, Lung Neoplasms, Middle Aged, Prognosis, Retrospective Studies

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Med Sci Monit 2022; 28:e937371

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750