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31 January 2019 : Clinical Research  

The Role of Axillary Lymph Node Dissection in Tubular Carcinoma of the Breast: A Population Database Study

Shuang-Long Chen1AE, Wen-Wen Zhang2AE, Jun Wang3F, Jia-Yuan Sun2F, San-Gang Wu3ABCDG*, Zhen-Yu He2AG

DOI: 10.12659/MSM.913077

Med Sci Monit 2019; 25:880-887

Abstract

BACKGROUND: The aim of this study was to investigate the role of axillary lymph node dissection on the outcome of patients with tubular carcinoma of the breast.

MATERIAL AND METHODS: Patients diagnosed with tubular carcinoma of the breast between 2000–2013 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Statistical analysis of the data was undertaken, including analysis of breast cancer-specific survival (BCSS).

RESULTS: Of the 5,645 patients identified on the SEER database with tubular carcinoma of the breast, 5,032 (89.4%) patients had undergone axillary lymph node dissection, with significantly increased rates after 2002 compared with rates between 2000–2001 (p <0.001), which stabilized between 2002–2013 (p=0.330). Axillary lymph node metastases were present in 6.1% of all patients and in 5.3% of patients with a tumor size ≤2 cm. Lymph node-positive disease was associated with patient age ≤65 years, intermediate-grade or high-grade tumors, and tumor size >2.0 cm. Axillary lymph node dissection was an independent prognostic indicator. The 10-year BCSS was 97.3% and 96.6% in patients with and without axillary lymph node dissection, respectively (p=0.002). The number of removed lymph nodes was not related to breast cancer-specific survival.

CONCLUSIONS: In patients with tubular carcinoma of the breast, lymph node status was not associated with significant breast cancer-specific survival. However, axillary lymph node dissection may still be considered for patients with for tubular carcinoma of the breast even in patients with a small tumor size.

Keywords: Breast Neoplasms, Lymph Node Excision, Risk Factors, Survival Analysis, Adenocarcinoma, Adult, Aged, Axilla, Breast, Lymph Nodes, Lymphatic Metastasis, Middle Aged, Prognosis, Retrospective Studies, Survival Rate, Treatment Outcome

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750