07 June 2019 : Meta-Analysis
Efficacy and Safety of “On-Demand” Dapoxetine in Treatment of Patients with Premature Ejaculation: A Meta-Analysis
Yuefeng Du12ABCDE, Yumei Jiang12ABCDE, Jing Zhang1ABCDEFG, Ge Tian1ABCD, Na Zhang1ABCEF, Dapeng Wu1ABCDEFG, Xiaojing Bai12ABCDEFG*DOI: 10.12659/MSM.913606
Med Sci Monit 2019; 25:4225-4232
Abstract
BACKGROUND: The aim of this study was to assess the efficacy and safety of “on-demand” dapoxetine in the treatment of premature ejaculation (PE).
MATERIAL AND METHODS: We performed a meta-analysis of intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), perceived control over ejaculation (PCOE), and drug-related adverse effects (AEs). We searched Medline, PubMed, Embase, CNKI, Wanfang, and VIP databases up to May 30, 2018 with the following search terms: “dapoxetine” or “SSRIs” and “premature ejaculation” or “sexual dysfunction”.
RESULTS: Our analysis included 11 RCTs (8521 cases and 4338 controls). We found that IELT, PGIC, and PCOE in PE patients with “on-demand” dapoxetine were significantly higher than in the control group, and we observed higher proportions in 60 mg vs. 30 mg dapoxetine. The AEs were mild and tolerable.
CONCLUSIONS: “On-demand” dapoxetine is effective and safe for patients with PE, and a dose of 60 mg may be more effective than 30 mg.
Keywords: Patients, premature ejaculation, Safety, Drug-Related Side Effects and Adverse Reactions, Ejaculation, Naphthalenes, Serotonin Uptake Inhibitors
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Editorial: The WHO Identifies Ebola Disease Due to Bundibugyo Virus as a Public Health Emergency of International Concern (PHEIC) as Vaccine Development Accelerates
DOI: 10.12659/MSM.954627
Med Sci Monit 2026; 32:e954627
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