26 March 2019 : Clinical Research
LINK-A Long Non-Coding RNA (lncRNA) Participates in Metastasis of Ovarian Carcinoma and Upregulates Hypoxia-Inducible Factor 1 (HIF1α)
Huijun Zhang1BCDEF, Bin Yao2ABCF, Shengchun Tang3CD, Ying Chen2ADE*DOI: 10.12659/MSM.913609
Med Sci Monit 2019; 25:2221-2227
Abstract
BACKGROUND: The functionality of LINK-A lncRNA as an oncogenic lncRNA has only been characterized in triple-negative breast cancer. The present study investigated the possible involvement of LINK-A in ovarian carcinoma.
MATERIAL AND METHODS: We enrolled 76 patients with ovarian carcinoma. Quantitative real-time PCR (qRT-PCR) was performed to analyze LINK-A expression in ovarian biopsies. Effects of LINK-A overexpression on HIF1α and cancer cell migration and invasion were assessed.
RESULTS: We found that LINK-A was significantly higher in ovarian carcinoma patients than in healthy controls in ovarian biopsies and in serum. LINK-A expression effectively distinguished patients with metastatic ovarian carcinoma from healthy controls. LINK-A overexpression promoted cancer cell migration and invasion, and also upregulated the expression of HIF1α.
CONCLUSIONS: LINK-A lncRNA may be involved in the metastasis of ovarian carcinoma by upregulating HIF1α.
Keywords: Diagnostic and Statistical Manual of Mental Disorders, Ovarian Neoplasms, Hypoxia-Inducible Factor 1, alpha Subunit, transcriptional activation
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