15 July 2019 : Clinical Research
Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of RemifentanilWenzhu Wang1ABDE, Qinghua Zhou2BDF, Changxiu Yuan1ACFG*
Med Sci Monit 2019; 25:5258-5262
BACKGROUND: The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil.
MATERIAL AND METHODS: A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the polymorphism of ABCB1 rs1045642 using the TaqMan-MGB probe, and they were divided into 3 groups – a genotype AA group, a genotype AG group, and a genotype GG group – based on different genotypes of ABCB1 rs1045642.
RESULTS: The comparisons showed that there were no differences in sex, age, body mass index (BMI), smoking, drinking status, or ASA class among the 3 groups (P˃0.05). The genotype GG group had higher consumption of Remifentanil than the genotype AA group (P˂0.05), but the genotype AG group was not different from the genotype AA and GG groups (P˃0.05). Comparison of the surgery duration revealed no difference among the 3 groups (P˃0.05). The analepsia time, autonomous respiratory recovery time, and orientation recovery time in the genotype GG group were longer than in the genotype AA group (P˂0.05), but the genotype AG group was not different from the genotype AA and GG groups (P˃0.05). There were no differences in adverse reactions among the 3 groups (P˃0.05).
CONCLUSIONS: ABCB1 gene polymorphism can affect the clinical efficacy of Remifentanil.
Keywords: Anesthesia and Analgesia, Polymorphism, Single Nucleotide, Treatment Outcome, ATP Binding Cassette Transporter, Subfamily B, Biomarkers, Pharmacological, Gene Frequency, Middle Aged, Nucleoside Transport Proteins, remifentanil
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